中国药理学通报2026，Vol.42Issue(3)：509-519,11.DOI:10.12360/CPB202507047
裸花紫珠调节巨噬细胞治疗反复性骨骼肌损伤
Callicarpa nudiflora Hook.ex Arn.promotes repair of recurrent skeletal muscle injury by modulating macrophages
摘要
Abstract
Aim To investigate the mechanism by which Callicarpa nudiflora Hook.ex Arn.(CN)regu-lates macrophages to promote repair following recur-rent skeletal muscle injury.Methods Rats were di-vided into control,model,and treatment groups.Re-current tibialis anterior muscle injury was induced in the model and treatment groups,with the treatment group receiving treatment via gavage.Tissue samples were collected at multiple time points,and repair pro-cesses and mechanisms were evaluated using histol-ogy,UPLC-HRMS,network pharmacology,and pro-tein detection.Macrophages treated with CN-containing serum were assessed for proliferation/migra-tion and JAK/STAT pathway activity.Results CN promoted early myogenic repair and reduced fibrosis.Network pharmacology revealed that core targets were enriched in cytokine-receptor interactions,JAK-STAT,and NF-κB signaling pathways.CN increased macrophage infiltration in injured muscle,enhanced macrophage proliferation and migration,and upregu-lated IL-6 and TNF-α levels during the acute phase.CN activated the JAK1/STAT3 signaling pathway in macrophages,promoted the release of inflammatory factors,upregulated the NF-κB signaling pathway,and stimulated satellite cell proliferation.Conclu-sions CN activates the JAK1/STAT3 axis in macro-phages,promotes the release of acute-phase inflamma-tory factors and NF-κB signaling pathway activation,and thereby enhances early repair of recurrent skeletal muscle injury.关键词
裸花紫珠/骨骼肌损伤/巨噬细胞/IL-6/JAK-STAT信号通路/NF-κB信号通路Key words
Callicarpa nudiflora Hook.ex Arn./skeletal muscle injury/macrophages/IL-6/JAK-STAT signaling pathway/NF-κB signaling pathway分类
医药卫生引用本文复制引用
郑凯,周理,袁仕国,李玉珍,林翠,叶宝飞,伍海燕,朱海,郑超,罗阳..裸花紫珠调节巨噬细胞治疗反复性骨骼肌损伤[J].中国药理学通报,2026,42(3):509-519,11.基金项目
国家自然科学基金资助项目(No 82360941) （No 82360941）
海南省自然科学基金项目(No 823RC596) （No 823RC596）
海南省卫生健康行业科研项目(No 22A200106) （No 22A200106）
海南省临床医学中心(琼卫医函[2021]276号) （琼卫医函[2021]276号）
