中国医学创新2026，Vol.23Issue(9)：40-45,6.DOI:10.3969/j.issn.1674-4985.2026.09.009
瑞芬太尼复合丙泊酚静脉泵注维持对腹腔镜胆囊切除术患者的影响
The Effect of Remifentanil Combined with Propofol Intravenous Pump Maintenance on Patients Undergoing Laparoscopic Cholecystectomy
摘要
Abstract
Objective:To explore the application effect of Remifentanil combined with Propofol intravenous pump maintenance in laparoscopic cholecystectomy.Method:A total of 121 patients who underwent laparoscopic cholecystectomy in Baiyin Hospital of Integrated Traditional Chinese and Western Medicine from January 2023 to February 2025 were randomly divided into two groups.The control group(60 cases)was treated with intravenous pumping of Propofol 3-4 mg/(kg·h)to maintain anesthesia,and the study group(61 cases)was treated with intravenous pumping of Remifentanil 8-10 μg/(kg·h)on the basis of the control group.The perioperative vital signs and oxidative stress indicators,postoperative pain and sedation scores,recovery quality and the occurrence of adverse reactions were compared between the two groups.Result:Ten minutes after the establishment of pneumoperitoneum,SBP,DBP,HR and SpO2 in both groups decreased compared with those 5 minutes before anesthesia induction and 5 minutes after anesthesia induction,but those in the study group were higher than those in the control group(P<0.05).15 minutes after extubation,SBP,DBP,HR and SpO2 in both groups increased compared with those 10 minutes after the establishment of pneumoperitoneum,and those in the study group were higher than those in the control group(P<0.05).15 minutes after extubation,the levels of norepinephrine(NE)and cortisol(Cor)in both groups increased compared with those 10 minutes after the establishment of pneumoperitoneum,and those in the study group were lower than those in the control group(P<0.05).At 6 and 12 hours after the operation,the numerical rating scale(NRS)scores of both groups were higher than those at 2 hours after the operation,but the scores of the study group were lower than those of the control group(P<0.05).2 hours after the operation,the sedation-restlessness score[motor activity assessment scale(MAAS)score]of the study group was lower than that of the control group,and the Ramsay sedation score was higher than that of the control group(P<0.05).The additional dosage of analgesic drugs within 48 hours after the operation and the incidence of adverse reactions in the study group were lower than those in the control group,and the recovery time of spontaneous breathing,the time to open eyes upon call,and the extubation time were earlier than those in the control group(P<0.05).Conclusion:In laparoscopic cholecystectomy,Remifentanil combined with Propofol intravenous pump maintenance can better achieve sedation and analgesia,improve perioperative vital signs and oxidative stress indicators,reduce the occurrence of adverse reactions,and has higher anesthesia practicality and safety.关键词
腹腔镜胆囊切除术/瑞芬太尼/丙泊酚Key words
Laparoscopic cholecystectomy surgery/Remifentanil/Propofol引用本文复制引用
闫永宏,汪柯柯,顾中华..瑞芬太尼复合丙泊酚静脉泵注维持对腹腔镜胆囊切除术患者的影响[J].中国医学创新,2026,23(9):40-45,6.基金项目
白银市科技计划项目(2023-1-47Y) （2023-1-47Y）
