中成药2026，Vol.48Issue(3)：816-821,6.DOI:10.3969/j.issn.1001-1528.2026.03.014
复心合剂对老年主动瓣狭窄诱发心力衰竭保守治疗患者的临床疗效
Clinical effects of Fuxin Mixture on elderly patients with heart failure induced by aortic valve stenosis following conservative treatment
摘要
Abstract
AIM To explore the clinical effects of Fuxin Mixture on elderly patients with heart failure induced by aortic valve stenosis following conservative treatment.METHODS Eighty-six patients were randomly assigned into control group(43 cases)for 2-month intervention of conventional treatment,and observation group(43 cases)for 2-month intervention of both Fuxin Mixture and conventional treatment.The changes in clinical effects,left ventricular function indices(end-diastolic diameter,mass index,remodeling index,ejection fraction),three-dimensional speckle-tracking echocardiography indices(left ventricular overall longitudinal strain,left ventricular overall circumferential strain,left ventricular overall radial strain),left ventricular myocardial work indices(overall work index,overall useful work,overall useless work),laboratory indices(ischemia-modified protein,N-terminal pro-B-type natriuretic peptide,macrophage inflammatory protein-1α),TCM syndrome scores,heart rate variability indices(root mean square of successive RR intervals,standard deviation of RR intervals,average standard deviation of NN intervals over 5 min segments)and safety indices were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05).After the treatment,the two groups displayed decreased end-diastolic diameter,mass index,remodeling index,mass index,remodeling index,mass index,remodeling index,mass index,remodeling index,mass index,remodeling index,overall useless work,laboratory indices,TCM syndrome scores,heart rate variability indices(P＜0.05),and increased overall work index,overall useful work,ejection fraction,three-dimensional speckle-tracking echocardiography indices(P＜0.05),especially for the observation group(P＜0.05).No adverse reactions were observable in the two groups.CONCLUSION For the elderly patients with heart failure induced by aortic valve stenosis following conservative treatment,Fuxin Mixture can safely and effectively enhance cardiac functions and improve left ventricular remodeling.关键词
复心合剂/常规治疗/主动瓣狭窄/心力衰竭/保守治疗/左心室功能/心肌做功/心率变异性Key words
Fuxin Mixture/conventional treatment/aortic valve stenosis/heart failure/conservative treatment/left ventricular functions/myocardial work/heart rate variability分类
医药卫生引用本文复制引用
张娟,张倩,丛丛,张冰睿,孔立..复心合剂对老年主动瓣狭窄诱发心力衰竭保守治疗患者的临床疗效[J].中成药,2026,48(3):816-821,6.基金项目
山东省自然科学基金面上项目(ZR2024MH244) （ZR2024MH244）
山东省自然科学基金联合基金重点支持项目(ZR2021LZY038) （ZR2021LZY038）
山东省中医药科技发展计划项目(2021M181) （2021M181）
山东省老年医学学会2021年科技攻关项目(LKJGG2021W106) （LKJGG2021W106）
齐鲁流派中医学术流派传承项目(鲁卫函[2022]93号) （鲁卫函[2022]93号）
山东省中医药特色疗法挖掘整理项目(3700020699) （3700020699）
