中国医院用药评价与分析2026，Vol.26Issue(3)：282-287,6.DOI:10.14009/j.issn.1672-2124.2026.03.006
基于网络药理学的咳速停糖浆治疗上呼吸道感染作用机制研究
Mechanism of Kesuting Syrup in the Treatment of Upper Respiratory Tract Infection Based on Network Pharmacology and Molecular Docking
摘要
Abstract
OBJECTIVE:To explore the mechanism of Kesuting syrup in the treatment of upper respiratory tract infection based on network pharmacology.METHODS:The active components and potential targets of Kesuting syrup were identified through screening the traditional Chinese medicine systems pharmacology database and analysis platform database,predictions from the Swiss Target Prediction platform,and literature data mining.Relevant targets associated with upper respiratory tract infections were identified through database searches in DrugBank,GeneCards,and OMIM.Protein-protein interaction analysis of drug-disease intersection targets was performed by using the STRING platform.Cytoscape software was used to construct the drug-disease-targets related network diagram.Gene ontology(GO)functional enrichment analysis and Kyoto encyclopedia of genes and genomes(KEGG)pathway enrichment analysis were conducted by using the R programming language.Molecular docking verification was performed through the AutoDockTools software.RESULTS:A total of 75 active components of Kesuting syrup were screened out,and 579 predicted targets were obtained.There were 544 targets related to upper respiratory tract infection,and 39 intersection targets were observed.GO enrichment analysis showed that the potential targets were mainly localized in cellular components such as the endomembrane system and extracellular space,and were involved in biological processes including cellular response to chemical stimulus and response to oxygen-containing compound via molecular functions such as signaling receptor activity and molecular transducer activity.KEGG pathway enrichment analysis revealed significant enrichment in 55 critical signaling pathways,including fluid shear stress and atherosclerosis,cAMP signaling pathway,calcium signaling pathway,and interleukin(IL)-17 signaling pathway.The molecular docking results showed that the active components quercetin,luteolin,kaempferol and β-sitosterol had low binding energy with target tumor necrosis factors,IL-6,IL-1β,prostaglandin endoperoxide synthase 2,the docking effect was good.CONCLUSIONS:This study initially reveals the mechanism of Kesuting syrup in the treatment of upper respiratory tract infection,and provides ideas for clinical application and subsequent mechanism research of Kesuting syrup.关键词
咳速停糖浆/上呼吸道感染/网络药理学/分子对接Key words
Kesuting syrup/Upper respiratory tract infection/Network pharmacology/Molecular docking分类
医药卫生引用本文复制引用
李嘉琪,韩梦晗,吴嘉瑞,王雪,苏雪纯,周纪颖,杨思昀,柴克燕,乔川琪,王郝嘉,赵彤..基于网络药理学的咳速停糖浆治疗上呼吸道感染作用机制研究[J].中国医院用药评价与分析,2026,26(3):282-287,6.基金项目
国家中医药管理局高水平重点学科建设项目-临床中药学(No.zyyzdxk-2023257) （No.zyyzdxk-2023257）
