中国实验动物学报2026，Vol.34Issue(3)：442-450,9.DOI:10.3969/j.issn.1005-4847.2026.03.012
慢性阻塞性肺疾病合并肺间质纤维化动物模型的研究进展
Research progress on animal models of comorbid chronic obstructive pulmonary disease and pulmonary interstitial fibrosis
摘要
Abstract
Chronic obstructive pulmonary disease(COPD)and pulmonary interstitial fibrosis(PIF)are chronic pulmonary diseases that severely impair lung function.COPD combined with PIF(COPD-PIF)exacerbates lung-tissue damage,accelerates disease progression,and significantly worsens patient prognosis.However,the exact pathogenesis of COPD-PIF remains unclear,and effective treatment options are still lacking.Animal models have recently played a crucial role in elucidating the pathological mechanisms of COPD-PIF and facilitating new drug development.Current COPD models are primarily established by single-factor induction(such as cigarette smoke exposure or lipopolysaccharide injection)or multi-factor combination method,while PIF models mainly rely on bleomycin induction.The administration route(e.g.,intratracheal instillation,aerosol inhalation,or intravenous injection)affects the stability and reproducibility of these models.Although various COPD-PIF animal models have been developed and utilized for research,challenges remain in establishing a standardized and reliable model that fully mimics human disease characteristics.Additionally,although the order in which COPD and PIF are induced may influence the pathological manifestations,there is no consensus in current studies.Further investigations into the pathogenesis of COPD-PIF and the identification of effective therapeutic strategies require more research focusing on optimizing modeling techniques,improving model stability and reproducibility,and developing animal models that better reflect the clinical characteristics of COPD-PIF.These efforts will contribute to advancing fundamental research and facilitating new drug development in this field.关键词
慢性阻塞性肺疾病/肺间质纤维化/慢性阻塞性肺疾病合并肺间质纤维化/动物模型/造模方法Key words
chronic obstructive pulmonary disease/pulmonary interstitial fibrosis/chronic obstructive pulmonary disease combined with pulmonary interstitial fibrosis/animal model/modeling method分类
生物科学引用本文复制引用
姜雨,丁羽,于健健,付立娜,蔡成森,王珺..慢性阻塞性肺疾病合并肺间质纤维化动物模型的研究进展[J].中国实验动物学报,2026,34(3):442-450,9.基金项目
国家中医药管理局科技司-山东省卫生健康委员会共建中医药科技项目(GZY-KJS-SD-2023-048),山东省医药卫生科技项目(202403020196),山东省中医药科技项目(Q-2023041).Funded by Traditional Chinese Medicine Science and Technology Project Co-Funded by the Department of Science and Technology of the National Administration of Traditional Chinese Medicine and the Shandong Provincial Health Commission(GZY-KJS-SD-2023-048),Shandong Province Medical Health Science and Technology Project(202403020196),Traditional Chinese Medicine Science and Technology Project of Shandong Province(Q-2023041). （GZY-KJS-SD-2023-048）
