中国实验动物学报2026，Vol.34Issue(3)：459-468,10.DOI:10.3969/j.issn.1005-4847.2026.03.014
基于中西医临床病证特点的骨骼肌损伤动物模型评价
Evaluation of skeletal muscle injury animal models based on characteristics of Chinese and western medicine clinical syndromes
摘要
Abstract
Skeletal muscle injury(SMI)is relatively common in clinical practice,and there are different understandings and approaches to its pathogenesis and treatment strategies between Chinese and western medicine.The development of animal models of SMI that can reflect the clinical characteristics of Chinese and western medicine is of great significance to the in-depth study of its pathogenesis and the exploration of effective treatment method.In this paper,starting from the Chinese and western medical etiology and pathogenesis,diagnostic criteria,and identification and typing of SMI,we conducted a comprehensive evaluation of the construction method and characteristics of the existing animal models and their compatibility with Chinese and western medical conditions.The result showed that the heavy falling blow model had the highest degree of agreement with Chinese and western medical conditions,with 69.6％of Chinese and Western medical agreement and 49.4％of Chinese medical agreement;followed by the exercise-induced model,with 49.8％of western medical agreement and 44.1％of Chinese medical agreement;and chemical stimulation and ischemia/reperfusion models had the lowest degree of agreement.Overall,the animal models of SMI involved in this paper were better than the Chinese medical model in terms of western medical agreement,and the existing models were difficult to correspond accurately with the Chinese medical diagnosis and typing.Therefore,the construction of animal models that can accurately reflect the characteristics of Chinese and western medicine and Chinese medicine patterns is still an important direction for future research.关键词
骨骼肌损伤/动物模型/中西医病证结合Key words
skeletal muscle injury/animal model/combination of Chinese and western medicine evidence and disease分类
生物科学引用本文复制引用
魏英俊,谢兴文,李鼎鹏,侯璇..基于中西医临床病证特点的骨骼肌损伤动物模型评价[J].中国实验动物学报,2026,34(3):459-468,10.基金项目
2024年兰州市科技局项目(2024-2-26),甘肃省名中医传承工作室建设项目(甘中医药发[2024]7号),2023年甘肃省高校产业支撑计划项目(2023CYZC-57),甘肃省财政厅2025年临床重点专科能力提升项目补助资金和提前下达2026年临床重点专科能力提升项目(甘财社[2025]143号).Funded by Project of Lanzhou Science and Technology Bureau in 2024(2024-2-26),Construction Project of Gansu Provincial Famous Traditional Chinese Medicine Inheritance Studio(Gansu Provincial Administration of Traditional Chinese Medicine Letter[2024]No.7),Gansu Province Higher Education Industry Support Plan Project(2023CYZC-57),the 2025 Clinical Key Specialty Capacity Enhancement Project Subsidy and the Advanced Allocation of 2026 Clinical Key Specialty Capacity Enhancement Project from the Gansu Provincial Department of Finance(Gan Cai She[2025]No.143). （2024-2-26）
