中国医院用药评价与分析2026，Vol.26Issue(3)：346-349,4.DOI:10.14009/j.issn.1672-2124.2026.03.020
3种甘草酸制剂治疗抗结核药物肝损伤的成本-效果比较
Cost-Effectiveness Comparison of Three Glycyrrhizic Acid Preparations in the Treatment of Anti-Tuberculosis Drug Induced Liver Injury
摘要
Abstract
OBJECTIVE:To evaluate the cost-effectiveness of magnesium isoglycyrrhizinate,glycyrrhizin ammonium cysteine and compound ammonium glycyrrhizin S in the treatment of anti-tuberculosis drug induced liver injury,and to provide theoretical reference for the rational selection of glycyrrhizic acid preparations.METHODS:A total of 195 patients with tuberculosis admitted into the Tuberculosis Department of the Fifth People's Hospital of Wuxi from Jan.2019 to Apr.2025 were retrospectively selected and divided into the group A(treated with magnesium isoglycyrrhizinate,69 cases),group B(treated with glycyrrhizin ammonium cysteine,63 cases)and group C(treated with compound ammonium glycyrrhizin S,63 cases)according to the hepatoprotective regimens,pharmacoeconomic evaluation was conducted by using cost-effectiveness analysis and incremental cost-effectiveness comparison analysis,and the sensitive analysis was performed.RESULTS:The overall effective rates of hepatoprotective treatment were respectively 89.86％(62/69),76.19％(48/63)and 71.43％(45/63)in group A,group B and group C.The cost-effectiveness ratios for the treatment regimens were respectively 6 442.03,7 603.26 and 7 891.54 in group A,group B and group C.According to the incremental cost-effectiveness ratios of the three hepatoprotective regimens,group A was the most economical,and the results of sensitivity analysis were consistent with the above findings.CONCLUSIONS:In the treatment of anti-tuberculosis drug induced liver injury,magnesium isoglycyrrhizinate demonstrates superior efficacy and cost-effectiveness compared with glycyrrhizin ammonium cysteine and compound ammonium glycyrrhizin S.关键词
异甘草酸镁/甘草酸单铵半胱氨酸/复方甘草酸单铵S/抗结核药物肝损伤/药物经济学Key words
Magnesium isoglycyrrhizinate/Glycyrrhizin ammonium cysteine/Compound ammonium glycyrrhizin S/Anti-tuberculosis drug induced liver injury/Pharmacoeconomics分类
医药卫生引用本文复制引用
濮嘉霖,杨锦艳,徒康宛,潘晓军,蔡海峰..3种甘草酸制剂治疗抗结核药物肝损伤的成本-效果比较[J].中国医院用药评价与分析,2026,26(3):346-349,4.基金项目
江苏省药学会科研项目(No.Q202037) （No.Q202037）
