中国畜牧杂志2026，Vol.62Issue(4)：91-99,9.DOI:10.19556/j.0258-7033.20250318-08
脂联素对动物内质网应激的调控作用研究进展
Research Progress on the Regulatory Effect of Adiponectin on Endoplasmic Reticulum Stress in Animals
摘要
Abstract
Endoplasmic reticulum(ER)stress is a key response of animal cells to protein folding imbalance,closely related to various diseases such as fatty liver disease,poultry follicular atresia,bovine mastitis,bovine ketosis,enteritis,etc.Adiponectin is a multifunctional hormone secreted by adipose tissue that has biological effects such as regulating glucose and lipid metabolism,insulin sensitization,anti-inflammatory,antioxidant stress,regulating cell apoptosis and autophagy.Researches have indicated that adiponectin can regulate ER stress,protein and lipid synthesis,as well as cell apoptosis and survival through multiple signaling pathways such as AMPK/PPAR α/mTOR,improving inflammation and glucose and lipid metabolism in the body,and playing an important role in livestock and poultry related diseases.This article reviews ER stress and its important signaling pathways,the impact of ER stress on livestock and poultry related diseases,and the synergistic regulation of ER stress by adiponectin through multiple pathways to improve the process of related diseases.The aim is to provide new ideas for the development of clinical drugs targeting ER stress and the regulation of livestock and poultry stress.关键词
脂联素/内质网应激/调控作用/畜禽Key words
Adiponectin/Endoplasmic reticulum stress/Regulatory role/Livestock and poultry分类
农业科技引用本文复制引用
刘思程,杜晓梦,于蕾,曹中赞,栾新红..脂联素对动物内质网应激的调控作用研究进展[J].中国畜牧杂志,2026,62(4):91-99,9.基金项目
国家自然科学基金(32372956、32272953) （32372956、32272953）
