中国实用儿科杂志2026，Vol.41Issue(3)：259-264,6.DOI:10.19538/j.ek2026030616
蛋白丢失性肠病1例
One case of protein-losing enteropathy
李迪 1叶晓琳 1成殷 2崔晓双 1王国丽 1傅玲玲 3张蕊 3吴捷1
作者信息
- 1. 国家儿童医学中心首都医科大学附属北京儿童医院消化科,北京 100045
- 2. 国家儿童医学中心首都医科大学附属北京儿童医院病理科,北京 100045
- 3. 国家儿童医学中心首都医科大学附属北京儿童医院血液病科,北京 100045
- 折叠
摘要
Abstract
This case involves a 6-month-old male infant who has been admitted to the hospital repeatedly due to diarrhea since the age of 2 months.Later,the diarrhea gradually worsened,accompanied by manifestations of protein-losing enteropathy(PLE)such as fever and edema.The patient visited Beijing Children's Hospital Affiliated to Capital Medical University on May 22,2025,and a multidisciplinary team(MDT)conducted joint diagnosis and treatment.The final confirmed diagnosis was Langerhans cell histiocytosis(LCH).After treatment with targeted anti-tumor drugs and symptomatic therapy,the infant's condition improved.The core challenge of this case lies in the clinical rarity of LCH presenting with gastrointestinal symptoms as the initial manifestation.For children with diarrhea,hematochezia,and fever that respond poorly to conventional treatment,especially those with multisystem damage,early gastrointestinal mucosal pathology combined with special immunohistochemical tests should be performed based on clinical manifestations to confirm the diagnosis as soon as possible.Attention should be paid to strengthening inter-departmental communication and administering specialized treatment at an early stage to improve the prognosis of such children.关键词
慢性腹泻/蛋白丢失性肠病/多学科协作诊疗/朗格罕细胞组织细胞增生症Key words
chronic diarrhea/protein-losing enteropathy/multidisciplinary team/Langerhans cell histiocytosis分类
医药卫生引用本文复制引用
李迪,叶晓琳,成殷,崔晓双,王国丽,傅玲玲,张蕊,吴捷..蛋白丢失性肠病1例[J].中国实用儿科杂志,2026,41(3):259-264,6.
