针灸推拿医学（英文版）2026，Vol.24Issue(2)：190-199,10.DOI:10.1007/s11726-026-1567-8
针灸干预阿尔茨海默病的神经炎症机制研究进展
Research progress on neuroinflammatory mechanisms of acupuncture-moxibustion intervening Alzheimer disease
摘要
Abstract
Relevant studies on acupuncture-moxibustion intervening Alzheimer disease(AD)were collected,sorted out,and summarized,and acupuncture-moxibustion plays its role in treating AD via the following aspects:inhibiting abnormal activation of microglia and astrocytes;correcting imbalanced polarization of microglia;upregulating the expression of triggering receptor expressed on myeloid cells 2(TREM2)and component 1q(C1q);downregulating nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3);regulating the release of proinflammatory/anti-inflammatory factors;reducing the release of cyclooxygenase-2(COX-2)and transforming growth factor-β1(TGF-β1);suppressing the abnormal activation of Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3),nuclear factor-κB(NF-κB),high mobility group box 1(HMGB1)/receptor for advanced glycation end products(RAGE),and p38 mitogen-activated protein kinase(p38 MAPK)pathways;and upregulating molecule levels of the interleukin(IL)-33/growth stimulating gene 2 protein(ST2)pathway.关键词
针灸疗法/针刺疗法/灸法/阿尔茨海默病/信号传导/神经炎症Key words
Acupuncture-moxibustion Therapy/Acupuncture Therapy/Moxibustion Therapy/Alzheimer Disease/Signal Transduction/Neuroinflammation分类
医药卫生引用本文复制引用
李丽,严兴科,马翠,魏玉婷,窦婷婷,谢雯婷,洪珏..针灸干预阿尔茨海默病的神经炎症机制研究进展[J].针灸推拿医学（英文版）,2026,24(2):190-199,10.基金项目
This study was supported by 2023 Key Talent Project of Gansu Province[2023年甘肃省省级重点人才项目,No.Gan Zu Tong Zi(2023)20 Hao] （2023）
2024 University Teacher Innovation Fund Project(2024年高校教师创新基金项目,No.2024A-082) （2024年高校教师创新基金项目,No.2024A-082）
Research Startup Fund Project for Invited Talents of Gansu University of Chinese Medicine(甘肃中医药大学引进人才科研启动基金项目,No.2024YJRC-06). （甘肃中医药大学引进人才科研启动基金项目,No.2024YJRC-06）
