中医临床研究2026，Vol.18Issue(1)：28-34,7.DOI:10.3969/j.issn.1674-7860.2026.01.004
基于"肺合皮毛"理论探讨皮肤菌群和肺动脉高压之间的因果关系及潜在通路预测
Exploring the causality and potential pathway prediction between skin microbiota and pulmonary arterial hypertension based on the theory of"lung associating with skin"
摘要
Abstract
Objective:Based on the theory of"lung associating with skin"in traditional Chinese medicine(TCM),this study aims to explore the causality between skin microbiota and pulmonary hypertension(PH)using the Mendelian randomization(MR)method,predict the potential pathways through which regulating the skin microbiota may intervene in PH,and provide new insights for clinical prevention and treatment strategies.Methods:Genome-wide association study(GWAS)data on skin microbiota and PH were obtained from the NHGRI-EBI GWAS Catalog and FinnGen database.MR analysis was performed using R software,with the inverse variance weighting(IVW)method as the primary approach to evaluate causalities.The robustness of the results was verified through heterogeneity tests,horizontal pleiotropy tests,and leave-one-out sensitivity analyses.The FUMA platform was used to identify genes adjacent to instrumental variables,and Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses of these adjacent genes were conducted via the DAVID database to explore potential pathways involved in the pathogenesis of PH.Results:MR analysis showed that Chryseobacterium(from the dorsal forearm),Corynebacterium(from the elbow fossa),and Burkholderiales(from the elbow fossa)were negatively associated with the risk of PH.Firmicutes(from the forehead sebum)was positively associated with the risk of PH.A total of 50 core genes were screened out.The GO and KEGG enrichment analyses suggested that these genes may be involved in the pathogenesis of PH mainly through the complement and coagulation cascades pathway and the peroxisome pathway.Conclusion:This study reveals,through MR analysis,that specific skin microbiota have a causality with the risk of PH,and predicts that their potential mechanisms of action involve the complement and coagulation cascades pathway and the peroxisome pathway.This provides a scientific basis for in-depth exploration of the pathogenesis of PH from the perspective of the"lung associating with skin"theory.关键词
肺动脉高压/皮肤菌群/肺合皮毛/孟德尔随机化/通路预测Key words
Pulmonary hypertension/Skin microbiota/Lung associating with skin/Mendelian randomization/Pathway prediction分类
医药卫生引用本文复制引用
胡中梅,郑天琪,方曾江楠,王时光..基于"肺合皮毛"理论探讨皮肤菌群和肺动脉高压之间的因果关系及潜在通路预测[J].中医临床研究,2026,18(1):28-34,7.基金项目
安徽省教育厅高校中青年人才培养项目(JNFX2024026) （JNFX2024026）
全国老中医药专家学术经验继承工作项目(国中医药人教函[2022]76号) （国中医药人教函[2022]76号）
安徽中医药传承创新科研项目(2024ZYYXH148) （2024ZYYXH148）
安徽中医药大学探索性科研项目(AHUCM2024TS106). （AHUCM2024TS106）
