中西医结合肝病杂志2026，Vol.36Issue(3)：387-391,5.DOI:10.3969/j.issn.1005-0264.2026.003.024
肝细胞癌中脂肪酸代谢的研究进展
Recent advances in fatty acid metabolism in hepatocellular carcinoma
摘要
Abstract
Hepatocellular carcinoma(HCC)is a globally prevalent malignant tumor,characterized by persistently high incidence and mortality rates.The pathogenesis of HCC is multifactorial,with dysregulated lipid metabolism emerging as a critical factor.In HCC,the anabolic pathways of fatty acid synthesis are markedly upregulated,with key enzymes such as ATP-citrate lyase,acetyl-CoA carboxylase,fatty acid synthase,and stearoyl-Coenzyme A desaturase 1 being overexpressed in HCC tissues,thereby facilitating tumor growth and progression.Moreover,fatty acid oxidation plays a vital role in HCC cells,especially under conditions of glucose deprivation,as it serves as an alternative energy source.Sterol regulatory element-binding proteins and peroxisome proliferators-activated receptors function as key regulatory factors that modulate the synthesis and catabolism of fatty acids.Strategic inhibition of these enzymes could effectively arrest tumor development,paving new avenues for cancer therapeutic interventions.Hence,this review synthesizes the research advancements in fatty acid metabolism-related proteins and genes in the occurrence and development of HCC,with the aim of providing novel perspectives for lipid metabolism-targeted therapeutic strategies against HCC.关键词
肝细胞癌/脂肪酸代谢/脂肪酸从头合成/脂肪酸氧化Key words
Hepatocellular carcinoma/fatty acid metabolism/de novo lipogenesis/fatty acid oxidation分类
医药卫生引用本文复制引用
纽维桥,蒋汉林,蒋宗赢,黄立宁,潘雨佳,吴建武..肝细胞癌中脂肪酸代谢的研究进展[J].中西医结合肝病杂志,2026,36(3):387-391,5.基金项目
苏州市基础研究-医学应用基础研究(No.SKYD2023141),苏州市临床医学中心建设项目(No.Szlcyxzxj202107),苏州市"科教兴卫"青年科技项目(No.KJXW2023040),苏州市应用基础研究(医疗卫生)科技创新项目(SYW2024028) （No.SKYD2023141）
