中山大学学报（医学科学版）2026，Vol.47Issue(2)：216-226,11.DOI:10.11714/jsysu.med.YX20250151
基于NLRP3-GSDMD通路的细胞焦亡调控与缺血性脑卒中的免疫治疗策略
Regulation of Pyroptosis via the NLRP3-GSDMD Pathway and Its Immunotherapeutic Strategy in Ischemic Stroke
摘要
Abstract
Ischemic stroke(IS)is a neurological disorder with high rates of disability and mortality worldwide,characterized by complex interactions between immune-inflammatory responses and various forms of cell death during its onset and progression.In recent years,pyroptosis,a form of programmed cell death mediated by inflammasomes,has attracted increasing attention for its critical role in post-stroke neuronal injury.Among the underlying mechanisms,the NOD-like receptor family pyrin domain-containing 3 inflammasome-Gasdermin D(NLRP3-GSDMD)pathway,as the central signaling axis of pyroptosis,plays a crucial regulatory role in immune responses and neuronal dysfunction following cerebral ischemia.However,current therapeutic strategies targeting this pathway remain limited by insufficient specificity and an incomplete understanding of its mechanisms of action.Therefore,this review summarizes the immuno-inflammatory pathology of IS,the mechanisms of the NLRP3-GSDMD pathway and pyroptosis,as well as emerging immunotherapeutic strategies targeting this signaling axis,aiming to provide insights and references for future research on pyroptosis-based immunomodulatory therapies for stroke.关键词
含吡啶结构域的NOD样受体家族蛋白3炎性小体-气道蛋白D通路/细胞焦亡/缺血性脑卒中/免疫炎症/治疗Key words
NLRP3-GSDMD pathway/pyroptosis/ischemic stroke/immune inflammation/treatment分类
医药卫生引用本文复制引用
万晨蕾,任彬彬..基于NLRP3-GSDMD通路的细胞焦亡调控与缺血性脑卒中的免疫治疗策略[J].中山大学学报（医学科学版）,2026,47(2):216-226,11.基金项目
中医药传承与创新人才工程(仲景工程)(CZ0325-10) （仲景工程）
2022年度河南省中医药拔尖人才培养项目专项(2022ZYBJ09) （2022ZYBJ09）
