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TDO2-Associated Tryptophan Metabolism Correlates with Impaired Tertiary Lymphoid Structure Maturation and Reduced B Cell Class Switching in Breast Cancer

Weiping Yang Wei Xiao Wenhao Xu Lijun Ren Xian Li Junhua Yu Ronghua Wang

Oncology Research2026，Vol.34Issue(3)：P.667-690,24.

Oncology Research2026，Vol.34Issue(3)：P.667-690,24.DOI:10.32604/or.2026.071122

TDO2-Associated Tryptophan Metabolism Correlates with Impaired Tertiary Lymphoid Structure Maturation and Reduced B Cell Class Switching in Breast Cancer

Weiping Yang ¹Wei Xiao ²Wenhao Xu ³Lijun Ren ¹Xian Li ¹Junhua Yu ¹Ronghua Wang⁴

作者信息

1. Department of Breast and Thyroid Surgery,Qingdao Chengyang People’s Hospital,Qingdao,266109,China
2. Department of Hematology,The Seventh Affiliated Hospital,Sun Yat-sen University,Guangdong,518107,China
3. Department of Oncology,Shanghai Medical College,Fudan University,Shanghai,200032,China
4. Rudong People’s Hospital/Affiliated Rudong Hospital of Xinglin College,Nantong University,Nantong,226007,China
折叠

摘要

关键词

Spatial transcriptomics/kynurenine/aryl hydrocarbon receptor(AhR)/tryptophan 2,3-dioxygenase(TDO2)/tertiary lymphoid structures(TLS)/breast cancer/tumor immune microenvironment

分类

医药卫生

引用本文复制引用

Weiping Yang,Wei Xiao,Wenhao Xu,Lijun Ren,Xian Li,Junhua Yu,Ronghua Wang..TDO2-Associated Tryptophan Metabolism Correlates with Impaired Tertiary Lymphoid Structure Maturation and Reduced B Cell Class Switching in Breast Cancer[J].Oncology Research,2026,34(3):P.667-690,24.

基金项目

supported by grants from the Beijing Xisike Clinical Oncology Research Foundation(No.Y-Young2024-0138) （No.Y-Young2024-0138）

China Postdoctoral Science Foundation(No.2024M750538) （No.2024M750538）

Qingdao Chengyang People’s Hospital Fund Project(No.202510300). （No.202510300）

Oncology Research

ISSN：0965-0407

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