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Four Isosteroidal Alkaloids from Fritillaria Alleviate Lipopolysaccharide-Induced Inflammation in vitro and in vivo through MyD88-and TRIF-Dependent Signaling Pathways

AGA Er-bu PAI Ming-xin ZHANG Meng-rui TSE Wai Ming TSE Kathy Wai Gaun LUO You-fu YE Ben-gui

Chinese Journal of Integrative Medicine2026，Vol.32Issue(1)：P.54-63,10.

Chinese Journal of Integrative Medicine2026，Vol.32Issue(1)：P.54-63,10.DOI:10.1007/s11655-025-4025-4

Four Isosteroidal Alkaloids from Fritillaria Alleviate Lipopolysaccharide-Induced Inflammation in vitro and in vivo through MyD88-and TRIF-Dependent Signaling Pathways

AGA Er-bu ¹PAI Ming-xin ²ZHANG Meng-rui ²TSE Wai Ming ³TSE Kathy Wai Gaun ³LUO You-fu ⁴YE Ben-gui⁵

作者信息

1. State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,West China Medical School,Sichuan University,Chengdu,610041,China Medical College of Xizang University,Lhasa,850002,China
2. Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University,Chengdu,610041,China
3. Nin Jiom Medicine Manufactory(H.K.)Limited,Hong Kong SAR,999077,China
4. State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,West China Medical School,Sichuan University,Chengdu,610041,China
5. Medical College of Xizang University,Lhasa,850002,China Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University,Chengdu,610041,China
折叠

摘要

关键词

Fritillaria/isosteroidal alkaloids/mouse leukemia cells of monocyte macrophage/inflammation/lipopolysaccharide

分类

医药卫生

引用本文复制引用

AGA Er-bu,PAI Ming-xin,ZHANG Meng-rui,TSE Wai Ming,TSE Kathy Wai Gaun,LUO You-fu,YE Ben-gui..Four Isosteroidal Alkaloids from Fritillaria Alleviate Lipopolysaccharide-Induced Inflammation in vitro and in vivo through MyD88-and TRIF-Dependent Signaling Pathways[J].Chinese Journal of Integrative Medicine,2026,32(1):P.54-63,10.

基金项目

Supported by the Major Science and Technology Research Project in the Science and Technology Projects of Xizang Axtonomoxs Region,China(Nos.XZ202301ZY0009G,XZ202201ZD0001G01/06)。（Nos.XZ202301ZY0009G,XZ202201ZD0001G01/06）

Chinese Journal of Integrative Medicine

ISSN：1672-0415

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