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Directed evolution of stereoselective enzymes meets click reactions: Asymmetric synthesis of chiral triazoles using a Cu(I)-compatible halohydrin dehalogenase

Shaixiao Tian Xinying Ge Qipeng Yan Min Li Qun Huang Xinhua Zhang Ming Ma Bo Chen Jian-bo Wang

Green Synthesis and Catalysis2026，Vol.7Issue(1)：P.75-82,8.

Green Synthesis and Catalysis2026，Vol.7Issue(1)：P.75-82,8.DOI:10.1016/j.gresc.2024.01.001

Directed evolution of stereoselective enzymes meets click reactions: Asymmetric synthesis of chiral triazoles using a Cu(I)-compatible halohydrin dehalogenase

Shaixiao Tian ¹Xinying Ge ¹Qipeng Yan ¹Min Li ¹Qun Huang ²Xinhua Zhang ¹Ming Ma ¹Bo Chen ¹Jian-bo Wang³

作者信息

1. Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research(Ministry of Education)and Key Department Laboratory of Phytochemical R&D of Hunan Province,College of Chemistry and Chemical Engineering,Hunan Normal University,Changsha 410081,China
2. School of Pharmacy and Bioengineering,Chongqing University of Technology,Chongqing 400054,China
3. Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research(Ministry of Education)and Key Department Laboratory of Phytochemical R&D of Hunan Province,College of Chemistry and Chemical Engineering,Hunan Normal University,Changsha 410081,China Key Laboratory of Multiple Organ Failure(Zhejiang University)Ministry of Education,Department of General Intensive Care Unit of the Second Affiliated Hospital and Institute of Pharmaceutical Biotechnology,Zhejiang University School of Medicine,Hangzhou 310058,China Zhejiang Provincial Key Laboratory for Microbial Biochemistry and Metabolic Engineering,Hangzhou 310058,China
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摘要

关键词

Directed evolution/Chemo-enzymatic synthesis/Halohydrin dehalogenases/Chiral triazoles/Asymmetric click reaction

分类

化学化工

引用本文复制引用

Shaixiao Tian,Xinying Ge,Qipeng Yan,Min Li,Qun Huang,Xinhua Zhang,Ming Ma,Bo Chen,Jian-bo Wang..Directed evolution of stereoselective enzymes meets click reactions: Asymmetric synthesis of chiral triazoles using a Cu(I)-compatible halohydrin dehalogenase[J].Green Synthesis and Catalysis,2026,7(1):P.75-82,8.

基金项目

support from the National Key Research and Development Program of China(No.2023YFA0914100/2023YFA0914102) （No.2023YFA0914100/2023YFA0914102）

the National Natural Science Foundation of China(Nos.22077029 and 22034002) （Nos.22077029 and 22034002）

the Science Fund for Distinguished Young Scholars of Hunan Province(No.2021JJ10034) （No.2021JJ10034）

support from the National Natural Science Foundation of China(No.22276049) （No.22276049）

M.M.acknowledge the support from the National Natural Science Foundation of China(No.22276050). （No.22276050）

Green Synthesis and Catalysis

ISSN：2666-5549

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