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Hippocampus-targeted BDNF gene therapy to rescue cognitive impairments of Alzheimer''s disease in multiple mouse models

Siqi Tang Wenshu Luo Shihao Wu Meng Yuan Jiashuo Wen Guoshen Zhong Leshan Shen Wei Jiang Cheng Cheng Xia Wu Xiao Xiao

Genes & Diseases2026，Vol.13Issue(2)：P.453-471,19.

Genes & Diseases2026，Vol.13Issue(2)：P.453-471,19.DOI:10.1016/j.gendis.2025.101649

Hippocampus-targeted BDNF gene therapy to rescue cognitive impairments of Alzheimer''s disease in multiple mouse models

Siqi Tang ¹Wenshu Luo ²Shihao Wu ³Meng Yuan ³Jiashuo Wen ³Guoshen Zhong ³Leshan Shen ⁴Wei Jiang ⁵Cheng Cheng ⁵Xia Wu ¹Xiao Xiao⁶

作者信息

1. School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China
2. Belief Biomed Inc,Shanghai 200237,China
3. School of Medicine,Yunnan University,Kunming,Yunnan 650106,China
4. School of Bioengineering,East China University of Science and Technology,Shanghai 200237,China
5. Belief Biomed Inc,Shanghai 200237,China School of Bioengineering,East China University of Science and Technology,Shanghai 200237,China
6. School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China Belief Biomed Inc,Shanghai 200237,China
折叠

摘要

关键词

AAVT42/Alzheime’s disease/Brain-derived neurotrophic factor/Cognitive impairment/Hippocampal RNA sequencing

分类

医药卫生

引用本文复制引用

Siqi Tang,Wenshu Luo,Shihao Wu,Meng Yuan,Jiashuo Wen,Guoshen Zhong,Leshan Shen,Wei Jiang,Cheng Cheng,Xia Wu,Xiao Xiao..Hippocampus-targeted BDNF gene therapy to rescue cognitive impairments of Alzheimer''s disease in multiple mouse models[J].Genes & Diseases,2026,13(2):P.453-471,19.

基金项目

supported by the National Key Research and Development Program of China(No.2021YFC2700803) （No.2021YFC2700803）

the National Natural Science Foundation of China(No.82471501,82360226). （No.82471501,82360226）

Genes & Diseases

ISSN：2352-4820

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