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PSMD2-Mediated MAPK Signaling Promotes Bladder Cancer Development and Immune Microenvironment Remodeling

Shuwen Sun Jingcheng Zhang Zongtai Zheng Yajuan Hao Tianyuan Xu Ji Liu Liang Sun Aimin Wang Yadong Guo Shiyu Mao Xu Zhang Yunfei Xu Yifan Chen Yang Yan

Oncology Research2026，Vol.34Issue(4)：P.736-759,24.

Oncology Research2026，Vol.34Issue(4)：P.736-759,24.DOI:10.32604/or.2025.072373

PSMD2-Mediated MAPK Signaling Promotes Bladder Cancer Development and Immune Microenvironment Remodeling

Shuwen Sun ¹Jingcheng Zhang ²Zongtai Zheng ³Yajuan Hao ⁴Tianyuan Xu ²Ji Liu ⁴Liang Sun ⁵Aimin Wang ⁵Yadong Guo ⁴Shiyu Mao ⁴Xu Zhang ⁶Yunfei Xu ⁴Yifan Chen ²Yang Yan²

作者信息

1. Department of Urology,Shanghai Tenth People’s Hospital,School of Medicine,Tongji University,Shanghai,200072,China Department of Urology,Bengbu First People’s Hospital,Bengbu,233000,China Urologic Cancer Institute,School of Medicine,Tongji University,Shanghai,200072,China Department of Nuclear Medicine,Shanghai Tenth People’s Hospital,School of Medicine,Tongji University,Shanghai,200072,China
2. Department of Urology,Shanghai Tenth People’s Hospital,School of Medicine,Tongji University,Shanghai,200072,China Department of Urology,Bengbu First People’s Hospital,Bengbu,233000,China Urologic Cancer Institute,School of Medicine,Tongji University,Shanghai,200072,China
3. Department of Urology,The Affiliated Guangdong Second Provincial General Hospital of Jinan University,Guangzhou,510317,China
4. Department of Urology,Shanghai Tenth People’s Hospital,School of Medicine,Tongji University,Shanghai,200072,China Urologic Cancer Institute,School of Medicine,Tongji University,Shanghai,200072,China
5. Department of Urology,Bengbu First People’s Hospital,Bengbu,233000,China
6. Bio-X Institutes(Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders),Shanghai Jiao Tong University,Shanghai,200240,China
折叠

摘要

关键词

Bladder cancer(BCa)/proteasome 26S subunit non-ATPase 2(PSMD2)/C-X-C motif chemokine ligand 14(CXCL14)/immune infiltration

分类

医药卫生

引用本文复制引用

Shuwen Sun,Jingcheng Zhang,Zongtai Zheng,Yajuan Hao,Tianyuan Xu,Ji Liu,Liang Sun,Aimin Wang,Yadong Guo,Shiyu Mao,Xu Zhang,Yunfei Xu,Yifan Chen,Yang Yan..PSMD2-Mediated MAPK Signaling Promotes Bladder Cancer Development and Immune Microenvironment Remodeling[J].Oncology Research,2026,34(4):P.736-759,24.

基金项目

supported by the National Natural Science Foundation of China Commission,Youth Project(No.82203150,No.82302304) （No.82203150,No.82302304）

Anhui Health Commission Research Project(No.2024Aa30184) （No.2024Aa30184）

The Bengbu City Health and Medical Research Project(BBWK2024A103) （BBWK2024A103）

Cultivation grant for clinical and basic integration research of Shanghai Tenth People’s Hospital(SYYYRH2025020) （SYYYRH2025020）

Doctoral Workstation Foundation of Guangdong Second Provincial General Hospital,China(Grant No.2022BSGZ011) （Grant No.2022BSGZ011）

Elevate Engineering Foundation of Guangdong Second Provincial General Hospital,China(Grant No.TJGC2022009) （Grant No.TJGC2022009）

Science and Technology Program of Guangzhou,China(2024A04J4159) （2024A04J4159）

China Postdoctoral Science Foundation(2021M702137) （2021M702137）

Natural Science Foundation of Chongqing(cstc2021jcyj-msxmX1176) （cstc2021jcyj-msxmX1176）

Chongming District Sustainable Development Science and Technology Innovation Initiative Project(CKY2022-30). （CKY2022-30）

Oncology Research

ISSN：0965-0407

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