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CRISPR-based genome editing reveals the roles of efflux pumps in Mycobacterium abscessus

Sishang Li Aofei Duan Lanyue Zhang Chunliang Wang Meiyi Yan Gai-Xian Ren Li-Ping Pan Yi-Cheng Sun

mLife2026,Vol.5Issue(1):P.68-82,15.
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mLife2026,Vol.5Issue(1):P.68-82,15.DOI:10.1002/mlf2.70048

CRISPR-based genome editing reveals the roles of efflux pumps in Mycobacterium abscessus

Sishang Li 1Aofei Duan 2Lanyue Zhang 3Chunliang Wang 2Meiyi Yan 2Gai-Xian Ren 2Li-Ping Pan 3Yi-Cheng Sun2

作者信息

  • 1. NHC Key Laboratory of Systems Biology of Pathogens,State Key Laboratory of Respiratory Health and Multimorbidity,National Institute of Pathogen Biology and Center for Tuberculosis Research,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing,China Beijing Jishuitan Hospital,Capital Medical University,Beijing,China
  • 2. NHC Key Laboratory of Systems Biology of Pathogens,State Key Laboratory of Respiratory Health and Multimorbidity,National Institute of Pathogen Biology and Center for Tuberculosis Research,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing,China
  • 3. Laboratory of Molecular Biology,Beijing Key Laboratory for Drug Resistance Tuberculosis Research,Beijing Chest Hospital,Capital Medical University,Beijing Tuberculosis and Thoracic Tumor Research Institute,Beijing,China
  • 折叠

摘要

关键词

CRISPR-Cas9/drug resistance/efflux pump/genome editing/Mycobacterium abscessus

分类

医药卫生

引用本文复制引用

Sishang Li,Aofei Duan,Lanyue Zhang,Chunliang Wang,Meiyi Yan,Gai-Xian Ren,Li-Ping Pan,Yi-Cheng Sun..CRISPR-based genome editing reveals the roles of efflux pumps in Mycobacterium abscessus[J].mLife,2026,5(1):P.68-82,15.

基金项目

supported by the National Key R&D Program of China(2022YFC2303200) (2022YFC2303200)

the National Natural Science Foundation of China(32370199) (32370199)

the CAMS Initiative for Innovative Medicine(2021-I2M-1-035) (2021-I2M-1-035)

the Beijing Jishuitan Research Funding(ZR-202520). (ZR-202520)

mLife

2097-1699

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