阿尔茨海默病及相关病2026，Vol.9Issue(2)：139-144,6.DOI:10.3969/j.issn.2096-5516.2026.02.012
基于神经炎症反应探讨肠道菌群与阿尔茨海默病相关研究进展
Research progress on gut microbiota and Alzheimer's disease based on neuroinflammatory responses
摘要
Abstract
Alzheimer's disease(AD)is characterized by key pathological features including amyloid-β(Aβ)deposition,abnormal tau hyperphosphorylation,and persistent neuroinflammation.Neuroinflammation runs throughout the disease course and is closely associated with synaptic injury and cognitive decline.In recent years,accumulating evidence has indicated that the gut microbiota(GM)is closely linked to the onset and progression of AD,and that it can modulate neuroinflammatory responses via the gut-brain axis,thereby exerting an important influence on AD.Therefore,based on available clinical association studies and mechanistic insights from experimental research,this review focuses on the multi-step,integrated mechanisms by which GM-mediated neuroinflammation contributes to AD,and systematically summarizes the key mechanisms and potential intervention strategies targeting the"GM-neuroinflammation-AD"axis,aiming to provide therapeutic references and a theoretical basis for the clinical prevention and treatment of AD.关键词
阿尔茨海默病/肠道菌群/神经炎症反应Key words
Alzheimer's disease/Gut microbiota/Neuroinflammation分类
医药卫生引用本文复制引用
张丽霞,张成舜,高亚雄,周强..基于神经炎症反应探讨肠道菌群与阿尔茨海默病相关研究进展[J].阿尔茨海默病及相关病,2026,9(2):139-144,6.基金项目
甘肃省临床重点专科能力提升项目(甘中医药医政函[2026]1号) （甘中医药医政函[2026]1号）
兰州市科技发展指导性计划(2025-5-134) （2025-5-134）
甘肃中医药大学附属医院针灸中心开放课题(ZJKF2220) （ZJKF2220）
