北京大学学报（自然科学版）2026，Vol.62Issue(2)：217-229,13.DOI:10.13209/j.0479-8023.2026.015
长链脂肪酸通过抑制髓源抑制性细胞延缓肿瘤进展
Long-Chain Fatty Acids Inhibit Myeloid-Derived Suppressor Cells to Delay Tumor Progression
刘鑫雨 1孔凡妮 1邓章雨滋 1杨竞 1陈虹杰1
作者信息
- 1. 北京大学生命科学学院,北京 100871
- 折叠
摘要
Abstract
To clarify the regulatory role and underlying mechanism of long-chain fatty acids(LCFAs)in the tumor immune microenvironment,this study focused on myeloid-derived suppressor cells(MDSCs)and various mouse tumor models.By employing in vitro and in vivo LCFA exposure and high-LCFA diet interventions,we analyzed the effects of LCFAs on the immunosuppressive function of MDSCs,CD8+T cell-mediated anti-tumor immunity,and tumor progression.The results demonstrated that treating cells with LCFAs both in vitro and in vivo significantly decreased the expression levels of characteristic immunosuppressive genes in monocytic MDSCs(M-MDSCs)and polymorphonuclear MDSCs(PMN-MDSCs).Animal experiments showed that mice fed a high-LCFA diet exhibited delayed tumor progression and prolonged survival across different cancer models.Furthermore,this LCFA-mediated inhibition of M-MDSCs and PMN-MDSCs correlates with enhanced CD8+T antitumor immunity,which is abolished in tumor-bearing nude mice.These results reveals a previously under-recognized role of LCFAs in the tumor immune microenvironment,implicating novel therapeutic strategies for cancer treatment.关键词
长链脂肪酸(LCFAs)/肿瘤免疫微环境/髓源抑制性细胞(MDSCs)/抗肿瘤免疫Key words
Long-chain fatty acids(LCFAs)/tumor immune microenvironment/myeloid-derived suppressor cells(MDSCs)/antitumor immunity引用本文复制引用
刘鑫雨,孔凡妮,邓章雨滋,杨竞,陈虹杰..长链脂肪酸通过抑制髓源抑制性细胞延缓肿瘤进展[J].北京大学学报（自然科学版）,2026,62(2):217-229,13.
