北京大学学报（医学版）2026，Vol.58Issue(2)：251-256,6.DOI:10.19723/j.issn.1671-167X.2026.02.005
靶向血管治疗在乳腺癌精准治疗中的分子机制与临床应用
Molecular mechanisms and clinical applications of anti-angiogenic therapy in preci-sion treatment of breast cancer
摘要
Abstract
Tumor angiogenesis is a crucial determinant of breast cancer progression and therapeutic response.This review first traces the proposal and evolutionary course of the tumor angiogenesis theory,and systematically collates its diverse occurrence patterns,including sprouting angiogenesis,intussuscep-tive angiogenesis,vascular mimicry and vascular co-option,while conducting an in-depth analysis of the heterogeneous characteristics of different patterns and their biological significance at various stages of tumor progression.At the molecular regulatory mechanism level,this paper focuses on summarizing the mechanisms of core regulatory networks,such as the hypoxia-inducible factor-1 axis,vascular endothelial growth factor/vascular endothelial growth factor receptor,platelet-derived growth factor/platelet-derived growth factor receptor,angiopoietin/angiopoietin receptor,and Delta-like ligand 4/Notch receptor signa-ling pathway.In addition,this paper comprehensively reviews the clinical exploration of anti-angiogenic therapy for breast cancer,and discusses the practical challenges faced by this therapeutic strategy,inclu-ding unstable efficacy,drug resistance,the lack of precise stratification biomarkers and treatment-related toxicities.Finally,this paper proposes future research directions oriented toward precision therapy,inclu-ding optimizing the vascular normalization window,developing patient stratification strategies based on multidimensional biomarkers,and deciphering tumor vascular heterogeneity by using spatial omics.These findings provide a theoretical reference for the optimization and innovation of anti-angiogenic therapy for breast cancer.关键词
肿瘤血管形成/乳腺癌/抗血管生成治疗/精准治疗Key words
Tumor angiogenesis/Breast cancer/Anti-angiogenic therapy/Precision medicine分类
医药卫生引用本文复制引用
王海,江一舟..靶向血管治疗在乳腺癌精准治疗中的分子机制与临床应用[J].北京大学学报（医学版）,2026,58(2):251-256,6.基金项目
国家自然科学基金(82403845)、全国博士后管理委员会博士后创新人才计划(A类)(BX20230092)、全国博士后管理委员会博士后面上项目(2025M772257)、上海市白玉兰浦江人才计划(24PJD019)、上海市自然科学项目(24ZR1413100)Supported by the National Natural Science Foundation of China(82403845) （82403845）
Postdoctoral Innovative Talents Support Program(Class A),National Postdoctoral Management Committee(BX20230092) （Class A）
General Program of China Postdoctoral Science Foundation,National Postdoctoral Management Committee(2025M772257) （2025M772257）
Shanghai Magnolia Pujiang Talent Program(24PJD019) （24PJD019）
Shanghai Natural Science Foundation Program(24ZR1413100) （24ZR1413100）
