北京大学学报（医学版）2026，Vol.58Issue(2)：319-326,8.DOI:10.19723/j.issn.1671-167X.2026.02.015
辅助生殖人群体脂率和体骨骼肌率与抑郁的相关性研究
Correlational research on body fat rate and skeletal muscle rate with depression in the population of assisted reproduction
摘要
Abstract
Objective:To investigate the relationship between body fat rates and skeletal muscle rates with depression among patients undergoing assisted reproductive technology(ART)treatments.Methods:A total of 885 infertility patients who underwent ART treatment at the Center for Reproductive Medicine of the First Affiliated Hospital of Anhui Medical University from July to October,2022 were se-lected using the convenience sampling method.The basic information of the patients was investigated,depression was investigated using the patient health questionnaire-9(PHQ-9),and human adiposity and body skeletal muscle rate data were measured using the InBody instrument with the principle of bioelectri-cal impedance analysis(BIA).Multiple linear regression,generalized linear model,and trend test were used to investigate the association between adiposity,skeletal muscle mass,and depression in the assisted reproduction population,as well as the dose-response relationship using restricted cubic spline(RCS)analysis.Results:The mean detection rate of depression in the ART population was 52.0％,with 55.5％in women and 45.5％in men.The average body fat rate was 28.01％,and the average body skeletal muscle rate was 39.73％.After correcting for confounders,the body fat rate was observed to be positive-ly associated with depression(β=0.07,95％CI:0.01,0.14),and the body skeletal muscle rate was negatively associated with depression(β=-0.12,95％CI:-0.24,-0.01).Trend-based tests showed a highly significant monotonically increasing trend in depression with the increasing body fat rate and the decreasing body skeletal muscle rate.These associations were significant(P＜0.05)in the male population and in the assisted reproduction population aged＞30 years.No significant non-linear associa-tions were found between the body fat rate,the skeletal muscle rate and depression in the overall ART-treated population(Pnon-linear＞0.05).Conclusion:The patients undergoing ART have a higher rate of depression detection,and their body fat and skeletal muscle rates are associated with the risk of depres-sion in ART patients.Interventions,such as weight control,body fat reduction,and an exercise diet that increases skeletal muscle and other body components are expected to reduce the incidence of depression in assisted reproduction.关键词
辅助生殖/脂肪/抑郁/骨骼肌/限制性立方样条Key words
Assisted reproduction/Fat/Depression/Skeletal muscle/Restricted cubic spline分类
医药卫生引用本文复制引用
宋晓欢,罗桂英,王婕妤,贾月迪,江飞,朱梦黎,王丹妮..辅助生殖人群体脂率和体骨骼肌率与抑郁的相关性研究[J].北京大学学报（医学版）,2026,58(2):319-326,8.基金项目
国家自然科学基金青年项目(72004001)、安徽省高校科研人文项目(2022AH050627)Supported by the Youth Program of the Na-tional Natural Science Foundation of China(72004001)and the Anhui University Scientific Research Humanities Project(2022AH050627) （72004001）
