北京中医药大学学报2026，Vol.49Issue(4)：565-572,8.DOI:10.3969/j.issn.1006-2157.2026.04.015
急性缺血性中风痰热证患者大动脉粥样硬化型与非大动脉粥样硬化型的临床特征比较
Comparison of clinical characteristics between large-artery atherosclerotic and non-large-artery atherosclerotic subtypes in acute ischemic stroke patients with phlegm-heat syndrome
摘要
Abstract
Objective To explore the clinical characteristics of patients with large-artery atherosclerosis type(LAA)and non-LAA with phlegm-heat syndrome in acute ischemic stroke and to provide a reference for the treatment of this disease.Methods Based on the China Stroke Registry for Patients with Traditional Chinese Medicine registration platform,a cross-sectional study was conducted to enroll patients with acute ischemic stroke and phlegm-heat syndrome with clear etiological classification from September 2022 to February 2025.The patients were divided into the LAA and non-LAA groups,and the demographic data,four traditional Chinese medicine(TCM)diagnosis information,neurological deficits,and laboratory indicators of the two groups were compared.Results A total of 196 patients were enrolled,with 110 and 86 patients in the LAA and non-LAA groups,respectively.No significant differences in age,sex,and modified Rankin Scale score at admission were observed between the two groups(P>0.05).In terms of TCM clinical manifestation,the frequency of weakness(81/110,73.64%),deep-colored urine(48/110,43.64%),choking cough after drinking(35/110,31.82%)in the LAA group were significantly higher than those in the non-LAA group(P<0.05):weakness(49/86,56.98%),deep-colored urine(24/86,27.91%),and choking cough after drinking(15/86,17.44%).Among tongue and pulse manifestations,cyanotic sublingual vessels(51/110,46.36%)were significantly more common in the LAA group than in the non-LAA group(26/86,30.23%).In contrast,petechia or ecchymosis on the tongue was significantly lower in the LAA group(13/110,11.82%)than in the non-LAA group(21/86,24.42%)(P<0.05).No significant differences in stroke severity or scores were observed between the two groups(P>0.05),nor were any significant differences in laboratory parameters(P>0.05).Conclusion Significant differences were observed in some TCM clinical manifestation and tongue and pulse manifestations between the LAA and non-LAA groups in patients with acute ischemic stroke with phlegm-heat syndrome.The incidence of weakness,deep-colored urine,choking cough after drinking,and cyanotic sublingual vessels is higher in the LAA group,whereas the incidence of petechia or ecchymosis on the tongue is relatively higher in the non-LAA group.These results provide a reference for the clinical diagnosis and treatment of the disease.关键词
缺血性中风/大动脉粥样硬化型/临床特征/神经功能/痰热证Key words
ischemic stroke/large-artery atherosclerosis type/clinical characteristics/neurological function/phlegm-heat syndrome分类
医药卫生引用本文复制引用
阙淬林,赖新星,周琮人,牟雨琳,高颖..急性缺血性中风痰热证患者大动脉粥样硬化型与非大动脉粥样硬化型的临床特征比较[J].北京中医药大学学报,2026,49(4):565-572,8.基金项目
国家重点研发计划项目(No.2022YFC3501100) （No.2022YFC3501100）
中央高水平中医医院临床科研业务费资助项目(No.DZMG-ZJXY-23011) （No.DZMG-ZJXY-23011）
北京中医药大学研究生自主科研课题(No.ZJKT2024040) National Key R&D Program of China(No.2022YFC3501100) （No.ZJKT2024040）
