滨州医学院学报2026，Vol.49Issue(2)：147-152,6.DOI:10.19739/j.cnki.issn1001-9510.2026.02.006
非小细胞肺癌中EGR1低表达与免疫细胞浸润及PD-L1表达相关性分析
Correlation analysis of low EGR1 expression with immune cell infiltration and PD-L1 expression in non-small cell lung cancer
摘要
Abstract
Objective To investigate the expression characteristics of early growth response factor 1(EGR1)in non-small cell lung cancer(NSCLC)and its correlation with immune cell infiltration and PD-L1 expression.Methods The expression differences of EGR1 in NSCLC were analyzed based on the cancer genome atlas(TCGA)and gene expression omnibus(GEO)databases.The TNMplot database was used to analyze the association between EGR1 and clinical features of NSCLC,and the Ka-plan-Meier Plotter database was applied to explore the correlation between EGR1 and lung cancer prognosis.The correlations be-tween EGR1 expression and immune cell infiltration,as well as the association between EGR1 and PD-L1 expression,were ana-lyzed with CELL×GENE and TIMER databases,and verified by immunohistochemical(SP)staining.Results EGR1 was ab-normally expressed in multiple tumors,and its expression in lung tumor tissues was significantly lower than that in normal tissues.EGR1 expression was significantly associated with tumor staging of NSCLC,but not with tumor metastasis.The overall survival(OS),post-progression survival(PPS),and progression-free survival(PFS)of NSCLC patients with low EGR1 expression were significantly shortened.EGR1 expression was positively correlated with infiltration of B cells,CD8+T cells,CD4+T cells,and macrophages,etc(P＜0.05).A positive correlation was found between EGR1 and PD-L1 expression(P＜0.01).Immunohistochemistry showed that EGR1 expression was significantly lower in the PD-L1 low-expression group(P=0.001 7).Conclusion In NSCLC,low EGR1 expression may lead to poor prognosis by affecting immune cells,and analyzing the correla-tion between EGR1 and PD-L1 can provide guidance for prognosis evaluation and immunotherapy of NSCLC.关键词
非小细胞肺癌/早期生长反应因子 1/免疫细胞浸润/程序性死亡配体 1Key words
non-small cell lung cancer/early growth response factor 1/immune cell infiltration/programmed death factor lig-and 1分类
医药卫生引用本文复制引用
张亚龙,刘蒙蒙,常文丽,朱玉红..非小细胞肺癌中EGR1低表达与免疫细胞浸润及PD-L1表达相关性分析[J].滨州医学院学报,2026,49(2):147-152,6.基金项目
滨州医学院科技计划(BY2021KJ40) （BY2021KJ40）
