滨州医学院学报2026，Vol.49Issue(2)：184-188,5.DOI:10.19739/j.cnki.issn1001-9510.2026.02.013
两样本孟德尔随机化分析口腔微生物与阿尔茨海默病的因果关联
Two-sample Mendelian randomization analysis of the causal relationship between oral microorganisms and Alzheimer's disease
摘要
Abstract
Objective To investigate the causal relationship between oral microbiota and Alzheimer′s disease(AD)risk with two-sample Mendelian randomisation and to address the problem of confounding bias inherent in observational studies.Methods We analyzed genome-wide association data from 488 285 individuals of European descent.Analyses were performed by inverse variance weighting(IVW),weighted median,MR-Egger,simple mode and weighted mode methods.Sensitivity analyses were corrected and exclusion validation.Results The IVW approach revealed a significant causal relationship between Streptococcus ASV0006 abundance and AD susceptibility(OR=1.000 157,95%CI=1.000 01 9-1.000295,P=0.025).Conclusion Men-delian randomization analysis results showed a significant positive association between the abundance of oral Streptococcus(ASV0006)and the increased risk of AD.The increased abundance of Streptococcus ASV0006may be a potential modifiable risk factor for AD.关键词
阿尔茨海默病/孟德尔随机化/口腔微生物组/链球菌Key words
Alzheimer′s disease/Mendelian randomization/oral microbiology/Streptococcus ASV0006分类
医药卫生引用本文复制引用
林萍,汤家敏,杜向阳,夏承东..两样本孟德尔随机化分析口腔微生物与阿尔茨海默病的因果关联[J].滨州医学院学报,2026,49(2):184-188,5.基金项目
安徽中医药大学临床科研项目(2025LCFZS46) （2025LCFZS46）
