川北医学院学报2026，Vol.41Issue(4)：469-472,4.DOI:10.3969/j.issn.1005-3697.2026.04.012
柴胡桂枝龙骨牡蛎汤加减治疗对肝郁气滞型失眠患者心理状态及睡眠的影响
Effect of modified Chaihu Guizhi Longgu Muli decoction on psychological status and sleep in patients with liver depression and qi stagnation type of insomnia
摘要
Abstract
Objective:To observe the effect of modified Chaihu Guizhi Longgu Muli decoction on the psychological status and sleep in patients with liver depression and qi stagnation type of insomnia.Methods:A total of 144 patients with insomnia of liver depression and qi stagnation type were selected,and they were divided into two groups based on treatment methods:the control group(n=72)received conventional western medicine treatment,whereas the treatment group(n=72)was treated with modified Chaihu Guizhi Longgu Muli decoction,and both groups were treated for 4 weeks.The clinical efficacy,TCM syndromes scores,psychological status[Hamilton Depression Scale(HAMD)and Hamilton Anxiety Scale(HAMA)scores],sleep quality[Pittsburgh Sleep Quality Index(PSQI),Insomnia Severity Index(ISI)scores]and serum neurotransmitters[Cortisol(Cor),Epinephrine(E)]before and after treatment and incidence of adverse reactions were compared between the two groups.Results:The overall response rate in the treatment group was higher compared to the control group(P<0.05).At 4 weeks of treatment,the scores of TCM syndromes,PSQI,ISI,HAMD and HAMA in the two groups were reduced compared with those before treatment,and the treatment group showed lower scores(P<0.05).The levels of Cor and E in both groups at 4 weeks of treatment were decreased compared to before treatment,and the treatment group showed lower(P<0.05).The incidence rates of adverse reactions in the treatment group were lower than those in the control group(P<0.05).Conclusion:Modified Chaihu Guizhi Longgu Muli decoction for patients with insomnia of liver depression and qi stagnation type can effectively regulate the psychological status and sleep,with few adverse reactions and high safety.关键词
失眠/肝郁气滞型/柴胡桂枝龙骨牡蛎汤/心理状态/睡眠质量Key words
Insomnia/Liver depression and qi stagnation type/Chaihu Guizhi Longgu Muli decoction/Psychological status/Sleep quality分类
医药卫生引用本文复制引用
白洁,李敏,王培,臧东静..柴胡桂枝龙骨牡蛎汤加减治疗对肝郁气滞型失眠患者心理状态及睡眠的影响[J].川北医学院学报,2026,41(4):469-472,4.基金项目
首都卫生发展科研专项项目(2022-2-7082) （2022-2-7082）
