川北医学院学报2026，Vol.41Issue(4)：488-491,4.DOI:10.3969/j.issn.1005-3697.2026.04.016
首次发作未用药注意缺陷与多动障碍患儿认知功能和脑分数低频波动幅度的变化及相关性
Changes and correlation analysis of cognitive function and brain fractional amplitude of low frequency fluctuation in children with first-episode unmedicated attention deficit and hyperactivity disorder
摘要
Abstract
Objective:To explore the changes and correlation of brain fractional amplitude of low frequency fluctuation(fALFF)and cognitive function in children with first-episode unmedicated attention deficit and hyperactivity disorder(ADHD).Methods:The case data of 46 children with first-episode unmedicated ADHD were retrospectively analyzed and the children were included in observation group,and 42 healthy children with physical examination during the same period were selected as control group.The differences in cognitive function[completed category count,persistent response count,persistent error count,and error response count of Wisconsin Card Sorting Test(WCST),and error rate of interference response inhibition evaluated by Simon task]and fALFF in brain regions were compared between the two groups.Pearson correlation analysis was used to analyze the correlation between cognitive function and fALFF in abnormal brain regions in children with ADHD.Results:Compared with control group,observation group had a low completed category count,and higher persistent response count,persistent error count,error response count and interference response inhibition error rate(P<0.05).Compared with control group,the fALFF values in the left superior postcentral gyrus and the right medial superior temporal gyrus were decreased in observation group while the fALFF values in the left caudate nucleus,posterior posterior cingulate gyrus and right superior temporal gyrus were increased(P<0.05).Pearson correlation analysis showed that fALFF values in the left superior postcentral gyrus and right medial superior temporal gyrus of ADHD children were negatively correlated with error rate of interference response inhibition(P<0.05).Conclusion:There is a certain correlation between cognitive function changes and brain fALFF in children with first-episode unmedicated ADHD,and cognitive impairment may be related to abnormal changes in brain regions.关键词
首次发作/未用药/注意缺陷与多动障碍/脑分数低频波动幅度/认知功能/相关性分析Key words
First-episode/Unmedicated/Attention deficit and hyperactivity disorder/Brain fractional amplitude of low frequency fluctuation/Cognitive function/Correlation analysis分类
医药卫生引用本文复制引用
白雨晨,黄环环,何凡..首次发作未用药注意缺陷与多动障碍患儿认知功能和脑分数低频波动幅度的变化及相关性[J].川北医学院学报,2026,41(4):488-491,4.基金项目
高层次公共卫生技术人才建设项目资助(学科带头人-02-01) （学科带头人-02-01）
首都卫生发展科研专项资助(2024-1-2123) （2024-1-2123）
