长春中医药大学学报2026，Vol.42Issue(4)：402-406,5.DOI:10.13463/j.cnki.cczyy.2026.04.006
基于"肾亏毒滞"与氧化应激相关性探讨狼疮性肾炎中医辨治
Exploration of TCM treatment based on syndrome differentiation of lupus nephritis based on the correlation between kidney deficiency and toxin stagnation and oxidative stress
摘要
Abstract
Oxidative stress refers to the process in which the imbalance between oxidative and antioxidant systems leads to damage caused by the accumulation of reactive oxygen species within cells.Lupus nephritis(LN)pathogenesis is associated with oxidative stress.Based on the theory"kidney deficiency and toxin stagnation",the key pathogenesis for treatment based on syndrome differentiation of LN is"kidney deficiency harboring toxins,toxins damaging kidney meridian".Its fundamental cause is the loss of kidney yin and latent toxins,the pathological reason is toxin accumulation with excessive heat and blood stasis obstructing kidney collaterals,and the root of the critical condition is deficiency caused by damage,leading to dual deficiency of yin and yang.The staged treatment targeting oxidative stress as an intervention point has been proposed,including the latent phase requiring pathogen elimination and source interception to resist oxidative stress and regulate immunity,the onset phase requiring immediate disease prevention and transformation to clear pathological products and suppress damage,and the exacerbation phase requiring both attack and tonify to improve the microenvironment and restore homeostasis.Specific treatment methods and prescription of medications require comprehensive assessment of the underlying mechanisms and evidence-based formulation.关键词
狼疮性肾炎/氧化应激/肾虚毒滞/伏毒Key words
lupus nephritis/oxidative stress/kidney deficiency and toxin stagnation/latent toxin分类
医药卫生引用本文复制引用
霍艺菲,李纪高,周全..基于"肾亏毒滞"与氧化应激相关性探讨狼疮性肾炎中医辨治[J].长春中医药大学学报,2026,42(4):402-406,5.基金项目
河南省中医药青苗人才第二批培养项目(豫卫中医函[2021]16号) （豫卫中医函[2021]16号）
全国老中医药专家学术经验继承项目(国中医药人教函[2022]76号) （国中医药人教函[2022]76号）
