磁共振成像2026，Vol.17Issue(3)：110-116,7.DOI:10.12015/issn.1674-8034.2026.03.016
抑郁症伴失眠的多模态磁共振成像研究进展
Multimodal magnetic resonance imaging findings in depression with comorbid insomnia
摘要
Abstract
Depression is a common mental disorder that imposes a substantial burden on individuals and society.Insomnia is one of the most prevalent and clinically persistent symptoms in depression and shows a close bidirectional relationship with its onset,progression,and outcome,often indicating greater symptom severity,poorer treatment response,and a higher risk of relapse.Accumulating evidence suggests that depression and insomnia may,at least in part,share overlapping neurobiological mechanisms.In recent years,the application of multimodal MRI has substantially advanced the investigation of the neural underpinnings of depression comorbid with insomnia.This review systematically summarizes recent findings from structural MRI(sMRI),diffusion tensor imaging(DTI),functional MRI(fMRI),arterial spin labeling(ASL),and magnetic resonance spectroscopy(MRS)studies in this field.We highlight converging evidence of alterations in gray matter structure,white matter microstructure,glymphatic system function,brain activity,functional connectivity,and neurochemical profiles in individuals with depression and comorbid insomnia.In addition,we discuss the limitations of the existing literature and outline directions for future research,with the goal of facilitating the identification of imaging-based biomarkers and informing precision medicine approaches in clinical practice.关键词
抑郁症/失眠/多模态成像/磁共振成像/扩散张量成像/磁共振波谱/类淋巴系统Key words
depression/insomnia/multimodal imaging/magnetic resonance imaging/diffusion tensor imaging/magnetic resonance spectroscopy/glymphatic system分类
医药卫生引用本文复制引用
程子璇,胡良波..抑郁症伴失眠的多模态磁共振成像研究进展[J].磁共振成像,2026,17(3):110-116,7.基金项目
The Joint Medical Research Project of Chongqing Municipal Science and the Technology Bureau and Health Commission(No.2024ZDXM013). 重庆市科卫联合医学科研项目(编号:2024ZDXM013) （No.2024ZDXM013）
