磁共振成像2026，Vol.17Issue(3)：161-167,7.DOI:10.12015/issn.1674-8034.2026.03.023
多模态MRI在职业性锰暴露神经毒性中的研究进展
Research progress of multimodal magnetic resonance imaging in occupational manganese exposure-induced neurotoxicity
摘要
Abstract
Chronic manganese exposure can adversely affect the central nervous system,resulting in motor and cognitive impairments.Advances in neuroimaging have enabled multimodal MRI to sensitively and non-invasively characterize structural,functional,and metabolic brain alterations in manganese-exposed individuals,even at early and subclinical stages.These imaging findings provide critical insights into the neurobiological mechanisms underlying manganese-induced neurotoxicity.This review synthesizes current evidence on the application of multiple MRI modalities in occupational manganese exposure,focusing on their ability to detect microstructural damage,functional network alterations,and potential imaging biomarkers.It also summarizes the current limitations of these studies and outlines future research directions,aiming to support mechanistic interpretation,early identification of manganese-related neural injury,and improved imaging-based risk assessment in occupational settings.关键词
锰/职业暴露/神经毒性/多模态磁共振成像/磁共振成像Key words
manganese/occupational exposure/neurotoxicity/multimodal magnetic resonance imaging/magnetic resonance imaging分类
医药卫生引用本文复制引用
高宇丽,吴佳昱,邬小平..多模态MRI在职业性锰暴露神经毒性中的研究进展[J].磁共振成像,2026,17(3):161-167,7.基金项目
Xi'an Science and Technology Program Project(No.23YXYJ0004,23YXYJ0078). 西安市科技计划项目(编号:23YXYJ0004、23YXYJ0078) （No.23YXYJ0004,23YXYJ0078）
