陆军军医大学学报2026，Vol.48Issue(8)：971-979,9.DOI:10.16016/j.2097-0927.202512117
基于黏膜免疫的胃肠道感染疫苗佐剂及递送系统的研究现状与展望
Current status and prospects of mucosal immunity-based vaccine adjuvants and delivery systems for gastrointestinal vaccines
摘要
Abstract
Vaccines represent the most cost-effective and efficacious approach for preventing gastrointestinal infections,and adjuvants play a pivotal role in enhancing and modulating immune responses.In this article,we summarize the mechanisms,advantages,and limitations of molecular adjuvants that induce gastrointestinal mucosal immune responses,as well as of delivery systems with dual adjuvant and carrier functions.We also analyze the principal challenges encountered in the development of such adjuvants,encompassing issues related to safety,efficacy,and adaptability.Furthermore,this article provides perspectives on future research directions for mucosal immunity-based adjuvants for gastrointestinal vaccines,including design of programmed adjuvants targeting specific gastrointestinal receptors,composite strategies integrating delivery systems with adjuvants,and adjuvant optimization tailored for special populations.关键词
胃肠道感染/疫苗/佐剂/递送系统Key words
gastrointestinal infections/vaccine/adjuvant/delivery system分类
医药卫生引用本文复制引用
李海波,王兆亿..基于黏膜免疫的胃肠道感染疫苗佐剂及递送系统的研究现状与展望[J].陆军军医大学学报,2026,48(8):971-979,9.基金项目
Supported by the General Program of National Natural Science Foundation of China(32270988)and the General Project of Natural Science Foundation of Chongqing(CSTB2024NSCQ-MSX0981). [基金项目]国家自然科学基金面上项目(32270988) （32270988）
重庆市自然科学基金面上项目(CSTB2024NSCQ-MSX0981) （CSTB2024NSCQ-MSX0981）
