动物营养学报2026，Vol.38Issue(4)：2382-2392,11.DOI:10.12418/CJAN2026.190
枯草芽孢杆菌对动物肠道屏障功能的调控作用及其在畜牧生产中的应用
Regulatory Effects of Bacillus subtilis on Intestinal Barrier Functions of Animals and Its Application in Livestock Production
摘要
Abstract
Bacillus subtilis(BS)is a widely used probiotic in animal husbandry presently,and often used as an additive in livestock production by adding BS to diet or drinking water.It is reported that BS can regulate the gut barrier functions of animals by maintaining the intestinal microecological balance,increasing the number of goblet cells in the intestinal tract,promoting the gene expression of mucin and tight junction proteins in the in-testine,improving the morphological structure of intestinal mucosa,and inhibiting the expression of pro-inflam-matory factors,as well as enhancing the antioxidant capacity of gut mucosa.Meanwhile,BS can effectively mitigate the structural damage and functional disorder of the intestinal barrier in animals caused by pathogenic bacteria,mycotoxins,and heat stress.Additionally,BS has been shown to increase the performance of ani-mals,improve the quality of meat and eggs,and alleviate the negative impacts of stress on animal production and health.This article expounded the regulatory effects and mechanisms of BS on the intestinal mucosal barrier functions of animals,and reviewed the research progress on the application of BS in livestock production,in order to provide references for regulating animal gut health by BS and the scientific application of BS in animal husbandry.[Chinese Journal of Animal Nutrition,2026,38(4):2382-2392]关键词
枯草芽孢杆菌/肠道屏障功能/动物/生产性能/调控机制/应用Key words
Bacillus subtilis/intestinal barrier function/animal/performance/regulatory mechanism/appli-cation分类
农业科技引用本文复制引用
陈继发,徐明明,曲湘勇,张佳鑫..枯草芽孢杆菌对动物肠道屏障功能的调控作用及其在畜牧生产中的应用[J].动物营养学报,2026,38(4):2382-2392,11.基金项目
江西省教育厅科技项目(GJJ211624) （GJJ211624）
宜春学院引进高层次人才科研启动基金(3360119022) （3360119022）
