动物营养学报2026，Vol.38Issue(4)：2534-2546,13.DOI:10.12418/CJAN2026.204
岩藻多糖对过敏性腹泻断奶仔猪生长性能、腹泻、肠道通透性和抗氧化能力的影响
Effects of Fucoidan on Growth Performance,Diarrhea,Intestinal Permeability and Antioxidant Capacity of Weaned Piglets with Allergic Diarrhea
摘要
Abstract
In this experiment,a model of allergic diarrhea in weaned piglets was established by soy antigen protein(SAP)and feeding fucoidan to investigate the alleviating effect of fucoidan on allergic diarrhea in weaned piglets.A total of 40 weaned piglets were randomly assigned to 5 groups with 8 piglets per group(n=8).The piglets in the 5 groups were fed different diets:basal diet(CT group),basal diet+2%SAP(SAP group),basal diet+2%SAP+100 mg/kg fucoidan(SAP+LF group),basal diet+2%SAP+200 mg/kg fu-coidan(SAP+MF group),basal diet+2%SAP+300 mg/kg fucoidan(SAP+HF group).The feeding trial was lasted for 6 days.The results showed as follows:1)compared with the CT group,dietary supplementation with SAP significantly reduced the average fecal score throughout the experimental period(P＜0.05),and sig-nificantly increased the severe diarrhea days of weaned piglets(P＜0.05).Compared with the SAP group,diet-ary supplementation with 200 mg/kg fucoidan significantly increased the average fecal score(P＜0.05),and supplementation with 100,200 and 300 mg/kg fucoidan significantly reduced the diarrhea rate(P＜0.05).2)Compared with the CT group,dietary supplementation with SAP significantly increased the contents of serum immunoglobulin E(IgE)and D-lactic acid(D-LA)as well as jejunal chymotrypsin activity(P＜0.05).Com-pared with the SAP group,dietary supplementation with 100,200 and 300 mg/kg fucoidan significantly re-duced the serum IgE content(P＜0.05).3)Compared with the CT group,dietary supplementation with SAP significantly decreased the villus height and the villus height to crypt depth ratio in the jejunum and ileum(P＜0.05),and significantly increased the crypt depth in the jejunum(P＜0.05).Compared with the SAP group,dietary supplementation with 300 mg/kg fucoidan significantly increased the villus height in the jejunum and il-eum(P＜0.05),dietary supplementation with 200 mg/kg fucoidan significantly decreased the crypt depth in the jejunum(P＜0.05),and dietary supplementation with 200 and 300 mg/kg fucoidan also significantly in-creased the villus height to crypt depth ratio in the jejunum(P＜0.05).4)Compared with the SAP group,diet-ary supplementation with 300 mg/kg fucoidan significantly upregulated the mRNA relative expression levels of zonula occludens-1(ZO-1),Claudin-1 and Occludin in the jejunum(P＜0.05).5)Compared with the CT group,dietary supplementation with SAP significantly reduced the activities of catalase(CAT)and glutathione peroxidase(GSH-Px)in serum(P＜0.05),and also significantly reduced CAT activity in the jejunum(P＜0.05).Compared with the SAP group,dietary supplementation with 200 and 300 mg/kg fucoidan significantly increased serum CAT and GSH-Px activities(P＜0.05),and dietary supplementation with 200 mg/kg fucoidan also significantly increased CAT activity in the jejunum(P＜0.05).Furthermore,soybean antigen protein sig-nificantly downregulated the expression of manganese superoxide dismutase(Mn-SOD)in the jejunum(P＜0.05),whereas 200 mg/kg fucoidan significantly upregulated the expression of CAT,copper-zinc superoxide dismutase(CuZn-SOD),Mn-SOD,glutathione peroxidase 1(GPx1)and glutathione peroxidase 4(GPx4)in the jejunum(P＜0.05).In conclusion,dietary supplementation with fucoidan can alleviate jejunal and ileal mu-cosal damage induced by SAP,inhibit the increase in intestinal permeability,upregulate the expression of tight junction protein and antioxidant enzyme genes,attenuate the decline in antioxidant capacity introduced by aller-gic reactions,and mitigate allergic diarrhea in weaned piglets.[Chinese Journal of Animal Nutrition,2026,38(4):2534-2546]关键词
岩藻多糖/断奶仔猪/过敏性腹泻/肠道通透性/抗氧化Key words
fucoidan/weaned piglets/allergic diarrhea/intestinal permeability/antioxidant分类
农业科技引用本文复制引用
徐元庆,韩丰韦,赵书珍,高博,张清月,史彬林..岩藻多糖对过敏性腹泻断奶仔猪生长性能、腹泻、肠道通透性和抗氧化能力的影响[J].动物营养学报,2026,38(4):2534-2546,13.基金项目
内蒙古自治区自然科学基金(2021BS03041) （2021BS03041）
国家自然科学基金(32460842) （32460842）
2025年内蒙古自治区农牧业重大技术协同推广计划"生猪种质提升与健康高效养殖关键技术集成推广与示范应用" （）
