动物营养学报2026，Vol.38Issue(4)：2886-2903,18.DOI:10.12418/CJAN2026.232
姜黄素对摄食高豆粕饲料黄姑鱼生长性能、抗氧化性能及脂肪代谢的影响
Effects of Curcumin on Growth Performance,Antioxidant Capacity and Lipid Metabolism of Nibea albiflora Fed a High Soybean Meal Diet
摘要
Abstract
This experiment was conducted to investigate the effects of curcumin on growth performance,an-tioxidant capacity and lipid metabolism of Nibea albiflora fed a high soybean meal diet.A total of 225 juvenile Nibea albiflora with an initial body weight of(4.93±0.06)g were randomly divided into three groups with three replicates per group and 25 fish per replicate.The fish were fed three isonitrogenous(crude protein con-tent of 50.00%)and isolipidic(crude lipid content of 12.00%)experimental diets for a 56-day culture period,including a basal diet(FM group),a diet with 50%fish meal replaced by soybean meal(SBM group)and a diet supplemented with 0.02%curcumin based on the SBM group(SBMC group).The results showed as fol-lows:1)compared with the FM group,the weight gain rate(WGR)and specific growth rate(SGR)of the SBM group were significantly decreased(P＜0.05),while the feed intake rate(FR)and feed conversion ratio(FCR)were significantly increased(P＜0.05).Compared with the SBM group,the WGR and SGR of the SBMC group were significantly increased(P＜0.05),while the FR and FCR were significantly decreased(P＜0.05).2)The ether extract content of whole fish in the SBMC group was significantly lower than that in the SBM group(P＜0.05).3)Severe lipid vacuolization was observed in liver cells of the SBM group,with nu-clear aggregation deviating from the cell center and massive lipid droplet accumulation.The intestinal villus height and microvillus height in the SBM group were significantly lower than those in the FM group(P＜0.05),and the gaps between intestinal epithelial cells were enlarged.Compared with the SBM group,the mor-phological structures of liver and intestine in the SBMC group were significantly improved.4)Compared with the FM group,the catalase(CAT)activity in liver and intestine of the SBM group was significantly decreased(P＜0.05),and the malondialdehyde(MDA)content was significantly increased(P＜0.05).Compared with the SBM group,the liver CAT activity of the SBMC group was significantly increased(P＜0.05),and the MDA content in liver and intestine was significantly decreased(P＜0.05).5)Compared with the FM group,the hepatic gene expressions of lipoprotein lipase(LPL),hormone-sensitive lipase(HSL),insulin-like growth factor-Ⅰ(IGF-Ⅰ),cholesterol 7α-hydroxylase(CYP7A1)and multidrug resistance-associated protein 4(MRP4)in the SBM group were significantly down-regulated(P＜0.05).Compared with the SBM group,the hepatic gene expressions of HSL,IGF-Ⅰ,CYP7A1 and MRP4 in the SBMC group were significantly up-regu-lated(P＜0.05).6)The GO functional enrichment analysis of differentially expressed genes(DEGs)between the SBM group and FM group,as well as between the SBMC group and SBM group,showed that DEGs were mainly enriched in the terms related to lipid metabolism,immune factor production and oxidative reaction regu-lation.The gene expression analysis of fatty acid synthase(FASN),LPL,HSL,CYP7A1 and MRP4,which are the key DEGs in bile secretion and glycerophospholipid metabolism pathways from the KEGG enrichment a-nalysis,showed that compared with the SBM group,the intestinal gene expressions of FASN and HSL in the SBMC group were down-regulated,while those of LPL,CYP7A1 and MRP4 were up-regulated.In conclu-sion,curcumin has a significant improving effect on growth performance,antioxidant capacity and lipid metab-olism of Nibea albiflora fed a high soybean meal diet,which may be related to the fact that curcumin can pro-mote bile acid secretion to maintain the homeostasis of enterohepatic circulation of bile acid and regulate the ex-pression of lipid metabolism-related genes to reduce lipid deposition in fish.[Chinese Journal of Animal Nutri-tion,2026,38(4):2886-2903]关键词
姜黄素/黄姑鱼/高豆粕饲料/生长性能/抗氧化性能/脂肪代谢Key words
curcumin/Nibea albiflora/high soybean meal diet/growth performance/antioxidant capacity/lipid metabolism分类
农业科技引用本文复制引用
付江文,马石鹏,张洪亮,徐冬冬,谭朋,陈睿毅,胡伟华,王立改..姜黄素对摄食高豆粕饲料黄姑鱼生长性能、抗氧化性能及脂肪代谢的影响[J].动物营养学报,2026,38(4):2886-2903,18.基金项目
浙江省自然科学基金项目(LY24C19004) （LY24C19004）
浙江省"尖兵""领雁"项目(2024C02012) （2024C02012）
舟山市渔业育种育苗中心项目(2025Y001-5) （2025Y001-5）
浙江省海洋水产研究所科技计划项目(HYS-CZ-202504,HYS-CZ-202509,HYS-ZX-202507) （HYS-CZ-202504,HYS-CZ-202509,HYS-ZX-202507）
