南方医科大学学报2026，Vol.46Issue(4)：761-769,9.DOI:10.12122/j.issn.1673-4254.2026.04.05
老年患者全麻期间颈总动脉血流的动态变化及其生理调控机制:一项前瞻性研究
Dynamic changes and physiological regulation of common carotid artery blood flow during general anesthesia in elderly patients:a prospective study
摘要
Abstract
Objective To explore the dynamic pattern and physiological regulation of common carotid artery(CCA)blood flow during general anesthesia in elderly patients.Methods A total of 193 elderly patients undergoing abdominal surgery were prospectively enrolled.Respiratory and hemodynamic variables and anesthetic depth of the patients were recorded throughout the perioperative period.CCA blood flow was measured at predefined time points using vector flow imaging.Heart rate,mean arterial pressure,end-tidal carbon dioxide,and bispectral index were included in a linear mixed-effects model,with patient ID as a random effect,to explore the physiological determinants of intraoperative CCA blood flow.Results CCA blood flow showed clear stage-related changes during general anesthesia.The mixed-effects model explained 52.0%of the variation in CCA blood flow(adjusted R²=0.520,P<0.001).Heart rate,mean arterial pressure,end-tidal carbon dioxide,and bispectral index were all significantly associated with CCA blood flow(all P<0.001).The standardized model further showed that the strength of these associations differed,with flow-related factors showing a stronger effect than blood pressure or heart rate alone.Surgical approach and patient position had no significant effect on CCA blood flow.Conclusion Intraoperative cerebral perfusion is not maintained by blood pressure alone but influenced jointly by ventilation,hemodynamic status,and anesthetic depth.Recognizing and managing these factors may help optimize cerebral perfusion during surgery.关键词
颈总动脉血流量/脑灌注/矢量血流成像/老年患者/全身麻醉Key words
common carotid artery blood flow/cerebral perfusion/vector flow imaging/elderly patients/general anesthesia引用本文复制引用
刘星扬,吴静涵,叶春艳,王锷,胡浩..老年患者全麻期间颈总动脉血流的动态变化及其生理调控机制:一项前瞻性研究[J].南方医科大学学报,2026,46(4):761-769,9.基金项目
国家自然科学基金联合基金项目(U24A20230) （U24A20230）
湖南省自然科学基金重点项目(2024JJ3051) Supported by Joint Fund Project of the National Natural Science Foundation of China(U24A20230). （2024JJ3051）
