广东医学2026，Vol.47Issue(3)：407-413,7.DOI:10.13820/j.cnki.gdyx.20251592
乳腺癌血清GDF3、sAxl、anti-CENPF水平预测前哨淋巴结转移的有效性
Predictive value of serum GDF3,sAxl,and anti-CENPF for sentinel lymph node metastasis in breast cancer
摘要
Abstract
Objective To investigate the relationship between serum levels of growth differentiation factor 3(GDF3),soluble Axl(sAxl),and anti-centromere protein F antibody(anti-CENPF)and sentinel lymph node(SLN)metastasis in breast cancer patients,and to evaluate their clinical predictive value.Methods A total of 200 female breast cancer patients treated at our hospital were enrolled.Based on pathological SLN results,patients were divided into SLN-positive(SLN+,n=93)and SLN-negative(SLN-,n=107)groups.Clinical and pathological characteristics were compared between the groups,and serum levels of traditional tumor markers(CEA,CA153)and GDF3,sAxl,anti-CENPF were measured.Three multivariate logistic regression models were constructed:Model 1(clinical-patho-logical characteristics+traditional tumor markers),Model 2(clinical-pathological characteristics+GDF3,sAxl,anti-CENPF),and Model 3(combined variables from Models 1 and 2).Receiver operating characteristic(ROC)curves were used to evaluate predictive performance,and DeLong's test was applied to compare the area under the curve(AUC)between models.Results The SLN+group exhibited larger tumor size,higher rates of lymphovascular inva-sion,higher histological grade Ⅲ proportion,and elevated serum CEA,CA153,GDF3,sAxl,and anti-CENPF com-pared to the SLN-group(P＜0.05).Multivariate logistic regression identified tumor size,histological grade,lympho-vascular invasion,CEA,CA153,GDF3,sAxl,and anti-CENPF as independent risk factors for SLN metastasis(P＜0.05).The AUCs for Models 1,2,and 3 were 0.781,0.804,and 0.886,respectively,with corresponding sensitivities of 72.0％,78.0％,and 90.1％and specificities of 70.0％,76.0％,and 87.0％.DeLong's test indicated that differ-ences in AUCs between the models were statistically significant(P＜0.05).Conclusion Serum GDF3,sAxl,and anti-CENPF levels are closely associated with SLN metastasis in breast cancer and represent independent risk factors.Combined assessment of these biomarkers with clinical-pathological features and traditional tumor markers significantly improves the predictive accuracy for SLN metastasis.关键词
乳腺癌/前哨淋巴结转移/生长分化因子3/可溶性Axl/抗着丝粒蛋白F抗体/预测效能Key words
breast cancer/sentinel lymph node metastasis/growth differentiation factor 3/soluble Axl/anti-centromere protein F antibody/predictive value分类
医药卫生引用本文复制引用
倪小锋,邵霞,张明..乳腺癌血清GDF3、sAxl、anti-CENPF水平预测前哨淋巴结转移的有效性[J].广东医学,2026,47(3):407-413,7.基金项目
浙江省科技计划项目(2022C37089) （2022C37089）
