广东医学2026，Vol.47Issue(3)：451-455,5.DOI:10.13820/j.cnki.gdyx.20252941
血清miR-708-3p、miR-147水平与急性心肌梗死病情的关系及对预后不良的预测价值
Association of serum miR-708-3p and miR-147 levels with disease severity and their prognostic value in acute myocardial infarction
摘要
Abstract
Objective To investigate the association between serum miR-708-3p and miR-147 levels and disease severity in patients with acute myocardial infarction(AMI),and to evaluate their predictive value for adverse prognosis.Methods Ninety-six patients with AMI admitted to our hospital between January 2024 and January 2025 were enrolled.Serum miR-708-3p and miR-147 levels were quantified using real-time fluorescence quantitative PCR.Patients were stratified according to Killip classification to assess disease severity.All patients were followed up for 3 months and categorized into a favorable prognosis group and an adverse prognosis group.Pearson correlation analysis was used to evaluate the relationship between miR-708-3p and miR-147 levels in patients with adverse outcomes.Multiva-riate logistic regression analysis was performed to identify independent prognostic factors.Receiver operating characteristic(ROC)curve analysis was conducted to assess predictive performance.Results Serum miR-708-3p(0.91±0.11 vs.0.75±0.09),miR-147(0.96±0.19 vs.0.65±0.17),and left ventricular ejection fraction(LVEF)[(43.28±5.27)％vs.(37.61±4.25)％]were significantly higher in the favorable prognosis group than in the adverse prognosis group(all P＜0.05).In patients with adverse outcomes,serum miR-708-3p and miR-147 levels were positively cor-related(r=0.593,P＜0.001).Serum miR-708-3p and miR-147 levels progressively decreased with increasing Kil-lip class(P＜0.05).Multivariate logistic regression analysis indicated that higher serum levels of miR-708-3p and miR-147 were independent protective factors against adverse prognosis(P＜0.05).The areas under the ROC curve(AUCs)for predicting adverse prognosis were 0.850 for miR-708-3p,0.796 for miR-147,and 0.947 for their com-bined detection.Combined prediction was significantly superior to either marker alone(Z=2.044 and 3.342;P=0.021 and 0.001,respectively).Conclusion Serum miR-708-3p and miR-147 levels are significantly reduced in patients with AMI and decrease further with increasing disease severity.Combined assessment of these two biomarkers provides high predictive value for adverse short-term prognosis.关键词
急性心肌梗死/病情程度/预后/miR-708-3p/miR-147Key words
acute myocardial infarction/severity of disease/prognosis/miR-708-3p/miR-147分类
医药卫生引用本文复制引用
陈颂,侯彩娜,邵艳奇..血清miR-708-3p、miR-147水平与急性心肌梗死病情的关系及对预后不良的预测价值[J].广东医学,2026,47(3):451-455,5.基金项目
河南省医学科技攻关计划项目(LHGJ20190561) （LHGJ20190561）
