赣南医科大学学报2026，Vol.46Issue(3)：195-199,5.DOI:10.3969/j.issn.2097-7174.2026.03.001
miR-92a在脑缺血再灌注损伤中的机制研究与治疗进展
The mechanism of miR-92a in cerebral ischemia-reperfusion injury and therapy progress
摘要
Abstract
Cerebral ischemia-reperfusion injury(CIRI)is a critical pathological process underlying ischemic stroke and other acute ischemic disorders.Its mechanisms involve inflammation,blood-brain barrier(BBB)disruption,oxidative stress,and neuronal apoptosis.As a key member of the miR-17-92 cluster,miR-92a plays an important regulatory role in multiple cell types of the neurovascular unit(NVU),including neurons,endothelial cells,pericytes,and astrocytes.Studies have shown that miR-92a aggravates inflammation,BBB dysfunction,oxidative stress,and neuronal apoptosis by inhibiting the expression of KLF2/4,NRG1,and antioxidative molecules such as HO-1 and SIRT6,thereby exacerbating brain injury.Therefore,developing new therapeutic strategies targeting the function and regulatory mechanisms of miR-92a has become a new focus in the field of CIRI research.This article reviews the multiple regulatory mechanisms of miR-92a in CIRI,aiming to provide new potential therapeutic targets and approaches for stroke.关键词
脑缺血再灌注损伤/miR-92a/脑卒中Key words
Cerebral ischemia-reperfusion injury/miR-92a/Stroke分类
医药卫生引用本文复制引用
钟惠敏,丁佳敏,陶爰名,黄宽,陈丽..miR-92a在脑缺血再灌注损伤中的机制研究与治疗进展[J].赣南医科大学学报,2026,46(3):195-199,5.基金项目
江西省自然科学基金重点项目(20232ACB206050) （20232ACB206050）
