赣南医科大学学报2026，Vol.46Issue(3)：248-254,261,8.DOI:10.3969/j.issn.2097-7174.2026.03.009
细胞外囊泡在新生儿疾病中的研究进展
Research progress of extracellular vesicles in neonatal diseases
摘要
Abstract
Neonatal diseases are the leading causes of infant mortality and long-term health complications.Its high mortality rate poses a severe challenge to modern intensive care medicine.Extracellular vesicles,biologically active membrane-bound structures,mediate critical intercellular functions including signal transduction,antigen presentation,and immune responses.This positions EVs as a novel therapeutic avenue for neonatal diseases.Current research primarily focuses on characterizing the properties of EVs derived from diverse cellular origins and subtypes,alongside evaluating their therapeutic potential in preclinical disease models.Preclinical studies have demonstrated significant efficacy of EVs in treating neonatal conditions such as retinopathy of prematurity,bronchopulmonary dysplasia,neonatal hypoxic-ischemic encephalopathy,and necrotizing enterocolitis,indicating their clinical feasibility in neonatal therapeutics.However,the clinical translation of EVs faces substantial challenges,including inherent heterogeneity and translational bottlenecks.Addressing these necessitates establishing standardized protocols,advancing clinical translation efforts,and exploring their diagnostic utility.关键词
细胞外囊泡/早产儿视网膜病变/支气管肺发育不良/新生儿缺氧缺血性脑病/坏死性小肠结肠炎Key words
Extracellular vesicles/Retinopathy of prematurity/Bronchopulmonary dysplasia/Hypoxic ischemic encephalopathy/Necrotizing enterocolitis分类
医药卫生引用本文复制引用
郑灏,陈妍,钟晓燕,林慧洁,蒋嘉豪,黄志华,江丽霞..细胞外囊泡在新生儿疾病中的研究进展[J].赣南医科大学学报,2026,46(3):248-254,261,8.基金项目
赣南医学院心脑血管疾病防治教育部重点实验室开放课题(XN201921) （XN201921）
研究生创新专项资金项目(YC2024-S831) （YC2024-S831）
