赣南医科大学学报2026，Vol.46Issue(3)：269-275,7.DOI:10.3969/j.issn.2097-7174.2026.03.012
艾司氯胺酮在围术期不同场景的临床应用进展
Clinical application progress of esketamine application in different perioperative scenarios
王嘉晟 1胡倩 1曹睿扬 1刘文楷 1王力峰2
作者信息
- 1. 赣南医科大学第一临床医学院
- 2. 赣南医科大学第一附属医院麻醉手术中心||赣南医科大学疼痛医学研究所||赣州市麻醉学重点实验室,江西 赣州 341000
- 折叠
摘要
Abstract
Esketamine is the S-enantiomer of ketamine.As a potent N-methyl-D-aspartate(NMDA)receptor antagonist with high affinity,it exhibits sedative,analgesic,and antidepressant properties,etc.The potency of esketamine is approximately twice that of racemic ketamine,along with several notable advantages:a rapid onset of action,mild respiratory depression,and reduced psychiatric adverse effects.In recent years,the perioperative application of esketamine has garnered increasing attention.It has shown promising clinical prospects,particularly in obstetric anesthesia,pediatric surgical anesthesia,orthopedic surgical anesthesia,painless diagnostic and therapeutic procedures,and special clinical scenarios.This paper summarizes the pharmacological properties,mechanism of action,and current clinical applications of esketamine in various clinical scenarios,with the goal of offering evidence to support its rational application in clinical practice.关键词
艾司氯胺酮/围术期的应用/镇静/镇痛/抗抑郁Key words
Esketamine/Perioperative application/Sedation/Analgesia/Antidepressant分类
医药卫生引用本文复制引用
王嘉晟,胡倩,曹睿扬,刘文楷,王力峰..艾司氯胺酮在围术期不同场景的临床应用进展[J].赣南医科大学学报,2026,46(3):269-275,7.
