中国妇幼健康研究2026，Vol.37Issue(4)：1-7,7.DOI:10.3969/j.issn.1673-5293.2026.04.001
妇科感染BV、VVC和TV与宫颈HR-HPV感染的相关性研究
A study on the correlation between BV,VVC,and TV infections and cervical HR-HPV infection
摘要
Abstract
Objective Based on large-scale national cervical cancer screening data,this study aims to explore the association between common gynecological infections and the risk of HR-HPV infection and its major genotypes(HPV16/52/58),providing evidence for cervical cancer prevention.Methods A cross-sectional study design was adopted,including 113 149 women aged 35-64 years who underwent HR-HPV genotyping tests in 39 districts across 11 provinces in 2021.Multivariate logistic regression was used to analyze the association between different gynecological infections and HR-HPV infection,and further to analyze the specific association with HPV16/52/58 types.Results The HR-HPV infection rates among women with bacterial vaginosis,vulvovaginal candidiasis,and trichomonal vaginitis were 15.22%,20.28%,and 21.16%,respectively,all significantly higher than those among women without the corresponding infections(9.88%,9.91%,9.89%)(χ2=124.889,211.466,252.304,all P<0.05).Bacterial vaginosis,vulvovaginal candidiasis,and trichomonal vaginitis were positively associated with HR-HPV infection.After full adjustment,the adjusted odds ratios(aOR)and 95%confidence intervals(CI)were 1.69(1.54-1.84),2.16(1.92-2.43),and 2.22(1.98-2.50),respectively.Type-specific analysis revealed that BV and TV were significantly associated with infections of HPV16,52,and 58;however,VVC showed significant type-specific association,being significantly associated with HPV52(aOR=1.89,95%CI:1.50-2.39)and HPV58(aOR=2.94,95%CI:2.30-3.77)infections,but not with HPV16 infection(aOR=0.97,95%CI:0.68-1.36).Conclusion BV,VVC,and TV are positively correlated with HR-HPV infection,and their effects show type-specific patterns.In cervical cancer prevention and control,the co-management of lower genital tract infections should be emphasized.关键词
高危型人乳头瘤病毒/妇科感染/细菌性阴道病/外阴阴道假丝酵母菌病/滴虫性阴道炎Key words
high-risk human papillomavirus/gynecological infection/bacterial vaginosis/vulvovaginal candidiasis/trichomonal vaginitis分类
医药卫生引用本文复制引用
闫梦可,杨业环,赵艳霞,马兰,杨艺林,郑睿敏..妇科感染BV、VVC和TV与宫颈HR-HPV感染的相关性研究[J].中国妇幼健康研究,2026,37(4):1-7,7.基金项目
国家重点研发项目(2023YFC2705501) （2023YFC2705501）
