中国妇幼健康研究2026，Vol.37Issue(4)：34-41,8.DOI:10.3969/j.issn.1673-5293.2026.04.005
孕期全血金属暴露与妊娠期糖尿病风险的关联
Association between maternal blood metal exposure during pregnancy and the risk of gestational diabetes mellitus
摘要
Abstract
Objective To evaluate the associations between early-pregnancy whole blood concentrations of lead(Pb),copper(Cu),zinc(Zn),calcium(Ca),magnesium(Mg),and iron(Fe)and the risk of gestational diabetes mellitus(GDM)using both single-metal and mixture-based analytical approaches.Methods A total of 191 pregnant women at 10-12+6 weeks of gestation were recruited from the Longhua District Maternal and Child Health Hospital in Shenzhen between June and October 2023.Blood samples were collected at 10-12+6 weeks of gestation,and metal concentrations were measured using atomic absorption spectrometry.GDM was diagnosed by a 75 g oral glucose tolerance test(OGTT)at 24-28 weeks of gestation.Multivariable logistic regression was applied to assess associations between individual metals and GDM risk,and Bayesian kernel machine regression(BKMR)was used to evaluate the effects of metal mixture exposure.Results Among the 191 participants,79(41.4%)were diagnosed with GDM.Blood Zn concentrations were significantly higher in the GDM group than in the non-GDM group(Z=-2.086,P=0.038).After multivariable adjustment,higher Zn levels were positively associated with GDM risk(OR=1.975,95%CI:1.036-3.766).BKMR analysis suggested an overall positive association between metal mixture exposure and GDM risk,with Zn showing a robust positive association and Cu exhibiting an inverse association.Conclusion Early pregnancy exposure to whole-blood metal mixture exposure was associated with GDM risk.Zn demonstrated a consistent positive association across multiple models,whereas Cu may have a protective effect.关键词
孕早期/妊娠期糖尿病/金属暴露/锌/BKMRKey words
early pregnancy/gestational diabetes mellitus/metal exposure/zinc/BKMR分类
医药卫生引用本文复制引用
郁璐嘉,朱雯,张罗丹,曾发,朱鹏,黄斌斌..孕期全血金属暴露与妊娠期糖尿病风险的关联[J].中国妇幼健康研究,2026,37(4):34-41,8.基金项目
国家自然科学基金(82103857) （82103857）
出生人口健康教育部重点实验室"本科生开放课题"(JKBK20246) （JKBK20246）
安徽省环境与人口健康重点实验室开放课题(JKYS20254) （JKYS20254）
省级大学生创新创业训练计划项目(S202410366063) （S202410366063）
广州市南沙区民生科技项目(2024MS003) （2024MS003）
