中国妇幼健康研究2026，Vol.37Issue(4)：54-61,8.DOI:10.3969/j.issn.1673-5293.2026.04.008
胎盘功能障碍与胎儿生长受限:基础研究与临床创新的桥梁
Placental dysfunction and fetal growth restriction:a bridge between basic research and clinical innovation
摘要
Abstract
Fetal growth restriction(FGR)is a significant clinical condition affecting neonatal prognosis,especially prevalent in regions with limited medical resources.This condition not only significantly increases the risk of perinatal mortality but is also closely associated with long-term neurodevelopmental disorders and cardiovascular metabolic diseases.From a pathogenic perspective,placental dysfunction is the core link of FGR,involving multiple pathological processes such as vascular dysregulation,metabolic disorders,and inflammatory responses.In terms of clinical diagnosis and treatment,current approaches mainly rely on a series of ultrasound monitoring,combined with hemodynamic indicators such as umbilical artery blood flow spectrum and uterine artery pulsatility index for comprehensive assessment.Treatment remains challenging,with a lack of specific drugs,and mainly involves nutritional support and individualized obstetric management plans.Currently,precision medicine offers new opportunities for the diagnosis and treatment of placenta-originated FGR.Therefore,through a systematic literature review,a deeper understanding of the pathogenesis and clinical management of placenta-originated FGR can be achieved.This understanding,on one hand,helps establish a standardized prenatal monitoring system and promotes precise diagnosis;on the other hand,it facilitates the establishment of a multidisciplinary collaborative diagnosis and treatment model,providing a basis for individualized treatment.关键词
胎儿生长受限/发病机制/精准医疗/胎盘功能障碍/产前监测Key words
fetal growth restriction/pathogenesis/precision medicine/placental dysfunction/prenatal monitoring分类
医药卫生引用本文复制引用
刘钰欣,朱亚男,张欣,鄢晨菲,杨学舟..胎盘功能障碍与胎儿生长受限:基础研究与临床创新的桥梁[J].中国妇幼健康研究,2026,37(4):54-61,8.基金项目
国家自然科学基金(82401976) （82401976）
国家卫生健康委医药卫生科技发展研究中心(WKZX2024DN0113) （WKZX2024DN0113）
湖北省自然科学基金(2023AFB238) （2023AFB238）
