国际口腔医学杂志2026，Vol.53Issue(3)：441-448,8.DOI:10.7518/gjkq.2026220
微小RNA-143/145基因簇在口腔鳞状细胞癌细胞信号通路调控中作用的研究进展
Research progress in the regulatory role of microRNA-143/145 gene cluster in signaling pathways of oral squa-mous cell carcinoma
郭文迪 1齐鲁 2王星1
作者信息
- 1. 新疆医科大学第一附属医院(附属口腔医院)口腔修复种植科 乌鲁木齐 830054||新疆维吾尔自治区口腔医学研究所 乌鲁木齐 830054
- 2. 新疆维吾尔自治区口腔医学研究所 乌鲁木齐 830054||新疆医科大学第二附属医院口腔科 乌鲁木齐 830063
- 折叠
摘要
Abstract
Oral squamous cell carcinoma(OSCC)is the most prevalent malignant neoplasm in the oral and maxillofa-cial region.Traditional surgical excision remains the primary treatment because of the lack of specific therapeutic ap-proaches.However,the resultant oral and maxillofacial defects severely impact patients'quality of life.Therefore,eluci-dating the molecular mechanisms regulating OSCC development is crucial.microRNA(miRNA)-143 and miRNA-145 are aberrantly expressed in OSCC and significantly participate in its pathogenesis.Studying the expression and target gene regulation of miRNA-143 and miRNA-145 in OSCC may help clarify its molecular mechanisms,confirm their value as biomarkers and molecular targets,and provide new insights for clinical diagnosis and treatment.关键词
微小RNA-143/微小RNA-145/口腔鳞状细胞癌/信号通路/靶基因Key words
microRNA-143/microRNA-145/oral squamous cell carcinoma/signaling pathway/target gene分类
生物科学引用本文复制引用
郭文迪,齐鲁,王星..微小RNA-143/145基因簇在口腔鳞状细胞癌细胞信号通路调控中作用的研究进展[J].国际口腔医学杂志,2026,53(3):441-448,8.
