摘要
Abstract
Slit guidance ligand 3(Slit3),a member of the axon guidance molecule family,not only plays a critical role in neural development,but also participates in a variety of physiological processes,including angiogenesis,cell migration,and organ development.Recent studies have demonstrated that Slit3 is downregulated in multiple types of tumors,which may be associated with promoter hypermethylation and microRNA-mediated regulation.By binding to Robo receptors,Slit3 is involved in regulating tumor cell proliferation,migration,invasion,and epithelial-mesenchymal transition,thereby affecting tumor progression and therapeutic response.In addition,Slit3 has the potential to serve as a biomarker for prognosis assessment,early diagnosis,and molecular classification in various cancers,and may also represent a novel target for tumor-targeted therapy.However,its clinical application still requires further validation through large-scale clinical studies.A deeper understanding of the biological functions of Slit3 and its mechanisms in different tumors may provide a theoretical basis for its clinical application and offer new directions for Slit3-targeted therapeutic strategies.关键词
Slit3/Robo受体/上皮-间充质转化/表观遗传修饰/miR-218Key words
Slit3/Robo receptor/epithelial-mesenchymal transition/epigenetic modification/miR-218分类
医药卫生
