神经损伤与功能重建2026，Vol.21Issue(4)：227-232,6.DOI:10.16780/j.cnki.sjssgncj.20251227
肠道菌群失调在药物难治性癫痫发病中的机制研究进展
Advances in Research on the Mechanisms of Gut Microbiota Dysbiosis in the Pathogenesis of Drug-Resistant Epilepsy
摘要
Abstract
Drug-resistant epilepsy(DRE)is a chronic brain disorder that is difficult to effectively control with antiepileptic drugs,accounting for nearly one-third of the global epilepsy patient population.Recent studies have revealed significant differences in the gut microbiota(GM)composition between DRE patients and healthy indi-viduals,suggesting that the gut microbiota may influence and regulate neurotransmitter metabolism,inflammato-ry responses,and blood-brain barrier function through the microbiota-gut-brain axis(MGBA),thereby participat-ing in the modulation of seizure activity.This article systematically reviews the research progress on the mecha-nisms underlying the regulation of gut microbiota for the treatment of DRE,aiming to provide a theoretical basis for the development of novel therapeutic strategies for DRE.关键词
药物难治性癫痫/肠道菌群/微生物-肠-脑轴/神经网络重塑/转运体假说Key words
drug-resistant epilepsy/gut microbiota/microbiota-gut-brain axis/neural network reshaping/trans-porter hypothesis分类
医药卫生引用本文复制引用
刘倩,张欣欣,金雯,韩晶,王倩,李在望..肠道菌群失调在药物难治性癫痫发病中的机制研究进展[J].神经损伤与功能重建,2026,21(4):227-232,6.基金项目
国家自然科学基金面上项目(脊髓损伤后EGFR活化介导神经毒性A1型星形胶质细胞增生的机制研究,No.82071364) （脊髓损伤后EGFR活化介导神经毒性A1型星形胶质细胞增生的机制研究,No.82071364）
广东省基础与应用基础研究基金(脑外伤后TREM2调控A2型星形胶质细胞活化的机制研究,No.2023A1515012525) （脑外伤后TREM2调控A2型星形胶质细胞活化的机制研究,No.2023A1515012525）
