神经损伤与功能重建2026，Vol.21Issue(4)：233-237,5.DOI:10.16780/j.cnki.sjssgncj.20251022
热休克蛋白调控帕金森病的作用机制研究进展
Research Progress on the Mechanism of Heat Shock Proteins in Regulating Parkinson's Disease
摘要
Abstract
Heat Shock Proteins(HSPs),as a crucial class of molecular chaperones in the human body,partici-pate in the regulation of various pathophysiological processes and play a vital role in maintaining human health.With the deepening of research,HSPs have been found to exert significant regulatory effects in Parkinson's dis-ease(PD),gradually emerging as a key therapeutic target for this neurodegenerative disorder.This article sum-marizes the pathological mechanisms through which HSPs are involved in PD by influencing alpha-synuclein(α-Syn)aggregation,mitochondrial function and oxidative stress,cellular autophagy,apoptosis,and neuroin-flammation,aiming to provide new research and clinical application directions for PD treatment.关键词
热休克蛋白/帕金森病/α-Syn聚集/氧化应激/神经炎症反应Key words
heat shock proteins/Parkinson's disease/α-Syn aggregation/oxidative stress/neuroinflammatory response分类
医药卫生引用本文复制引用
付夏艳,东红,李想,刘金龙..热休克蛋白调控帕金森病的作用机制研究进展[J].神经损伤与功能重建,2026,21(4):233-237,5.基金项目
甘肃省名中医传承工作室(甘中医药科教函[2026]1号) （甘中医药科教函[2026]1号）
