神经损伤与功能重建2026，Vol.21Issue(4)：242-245,4.DOI:10.16780/j.cnki.sjssgncj.20241112
磁共振波普技术在神经退行性疾病中的应用研究
Application of Magnetic Resonance Spectroscopy Technique in Neurodegenerative Diseases
摘要
Abstract
Magnetic Resonance Spectroscopy(MRS),as a non-invasive molecular imaging technique,en-ables the quantitative detection of changes in cerebral metabolites,providing crucial insights into the patho-physiology,early diagnosis,and therapeutic monitoring of neurodegenerative diseases.This review summa-rizes the applications of MRS in Alzheimer's disease(AD),Parkinson's disease(PD),multiple sclerosis(MS),and type 2 diabetes-related cognitive impairment.Studies have shown that MRS can detect early abnor-malities in neurotransmitter metabolism in the hippocampus in AD;reveal fluctuations in gamma-aminobutyr-ic acid(GABA)levels and their response to dopamine therapy in PD;identify energy metabolic alterations as-sociated with fatigue severity in MS;and demonstrate associations between prefrontal metabolites and glyce-mic control in cognitive impairment related to type 2 diabetes.Although currently limited by issues such as low sensitivity and complex signal interpretation,advances in high-field technology,ultra-fast sequences,and multimodal integration suggest broad prospects for MRS in the precise diagnosis and dynamic monitoring of neurodegenerative diseases.关键词
神经退行性变/磁共振波谱成像/阿尔茨海默病/帕金森病/多发性硬化/Ⅱ型糖尿病型认知障碍Key words
neurodegeneration/magnetic resonance spectroscopy/Alzheimer's disease/Parkinson's dis-ease/multiple sclerosis/cognitive impairment with type 2 diabetes分类
医药卫生引用本文复制引用
李一杰,韩英妹,张衡,徐慧勇,冯泽,李伟庆,王丰..磁共振波普技术在神经退行性疾病中的应用研究[J].神经损伤与功能重建,2026,21(4):242-245,4.基金项目
黑龙江省自然科学基金资助项目(针刺四关穴对遗忘型MCI脑微结构及功能网络重塑的MRI研究,No.LH2023H065) （针刺四关穴对遗忘型MCI脑微结构及功能网络重塑的MRI研究,No.LH2023H065）
