广西医科大学学报2026，Vol.43Issue(2)：151-160,10.DOI:10.16190/j.cnki.45-1211/r.2026.02.002
多模式预康复对老年结直肠癌患者术后应激反应、肠功能及营养状况的影响
Effects of multimodal prehabilitation on stress response,intestinal function and nutritional status in elderly patients after colorectal cancer surgery
摘要
Abstract
Objective:To investigate the impact of multimodal prehabilitation on the stress response,intestinal function and nutritional status in elderly patients after colorectal cancer surgery.Methods:A randomized con-trolled trial was conducted,enrolling 192 elderly patients with colorectal cancer admitted to the Department of Colorectal and Anorectal Surgery at the First Affiliated Hospital of Guangxi Medical University from April 2023 to May 2024.They were randomly divided into the experimental group and the control group,with 96 patients in each group,using the random number table method.The control group received standard care,while the experi-mental group underwent multimodal prehabilitation.The stress responses,postoperative intestinal function recov-ery,psychological states and nutritional status of the two groups of patients were compared.Results:The time of first flatus passage and the time of first defecation in the experimental group were shorter than those in the control group(both P＜0.05).Through repeated-measures analysis of variance,the main effects of heart rate,systolic blood pressure,and diastolic blood pressure in both groups of patients due to the time factor and the group factor,as well as the interaction effect of time×group,were statistically significant(all P＜0.05).There was a statisti-cally significant difference in the main effect of serum albumin time in both groups(F=60.763,P＜0.001),while the main effect of group(F=0.444,P=0.506),and the interaction effect of time×group(F=0.422,P=0.725)were not statistically significant.The hospital anxiety and depression scale-anxiety subscale(HADS-A)scores of the experimental group on postoperative day 3 were lower than those of the control group(P=0.003).The incidence of postoperative complications in the experimental group and the control group was 9.38%and 12.50%respec-tively,and there was no statistically significant difference between the two groups(χ²=0.481,P=0.488).Conclu-sion:Multimodal prerehabilitation can promote the recovery of intestinal function in elderly patients with colorec-tal cancer after surgery,stabilize physiological indicators,and alleviate postoperative psychological anxiety.How-ever,its underlying mechanism related to nutritional status needs further investigation.关键词
多模式预康复/结直肠癌/应激反应/肠功能/营养状况/医院焦虑抑郁量表/抑郁分量表/焦虑分量表Key words
multimodal prehabilitation/colorectal cancer/stress response/intestinal function/nutritional status/hospital anxiety and depression scale/hospital anxiety and depression scale-anxiety subscale/hospital anxiety and depression scale-depression subscale分类
医药卫生引用本文复制引用
莫思敏,钟荣桂,韦瑞丽,谢明杰,黄德斌..多模式预康复对老年结直肠癌患者术后应激反应、肠功能及营养状况的影响[J].广西医科大学学报,2026,43(2):151-160,10.基金项目
广西自然科学基金资助项目(2025GXNSFAA069940) （2025GXNSFAA069940）
广西壮族自治区卫生健康委员会自筹经费科研课题(Z-A20230568) （Z-A20230568）
